1-bromo-3,4-difluoro-2-methoxybenzene

Base Information

• Chemical Name: 1-bromo-3,4-difluoro-2-methoxybenzene
• CAS No.: 888318-22-7
• Molecular Formula: C7H5BrF2O
• Molecular Weight: 223.017
• Hs Code.: 2909309090
• Mol file: 888318-22-7.mol

Synonyms:1-bromo-3,4-difluoro-2-methoxybenzene;6-Bromo-2,3-difluoroanisole

Chemical Property of 1-bromo-3,4-difluoro-2-methoxybenzene

Chemical Property:

• Boiling Point: 195.7±35.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.615±0.06 g/cm3(Predicted)
• LogP: 2.73590
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ,99.9%, ^*data from raw suppliers

1-Bromo-3,4-difluoro-2-methoxybenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-bromo-3,4-difluoro-2-methoxybenzene

There total 3 articles about 1-bromo-3,4-difluoro-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

→ 1-bromo-3,4-difluoro-2-methoxy-benzene (888318-22-7)

Guidance literature:

Reference yield: 92.0%

6-bromo-2,3-difluoro-phenol (186590-23-8) + methyl iodide (74-88-4) → 1-bromo-3,4-difluoro-2-methoxy-benzene (888318-22-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 150 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1021/jm300912k

Reference yield:

2,3-difluorophenol (6418-38-8) → 1-bromo-3,4-difluoro-2-methoxy-benzene (888318-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: isopropylamine; N-Bromosuccinimide / dichloromethane / 0.5 h / -10 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C

With N-Bromosuccinimide; potassium carbonate; isopropylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

6-bromo-2,3-difluoro-phenol

methyl iodide

2,3-difluorophenol

Downstream raw materials:

4-(3,4-difluoro-2-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

4-(3,4-difluoro-2-methoxy-phenyl)-piperidine

8-chloro-3-(cyclopropylmethyl)-7-[4-(3,4-difluoro-2-methoxyphenyl)-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

4-(3,4-difluoro-2-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "9H-PYRIMIDO[4,5-B]INDOLES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS". Paragraph 1017. . Retrieved 2015/09/28.
• 2、 -. "RADIOLABELLED mGLuR2 PET LIGANDS". Page/Page column 32. . Retrieved 2012/05/31.