tert-butyl 4-((3-(2-(methylthio)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((3-(2-(methylthio)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate
CAS No.:1386398-91-9
Molecular Formula:C₂₁H₂₈N₈O₂S
Molecular Weight:456.572
Hs Code.:
Mol file:1386398-91-9.mol

Synonyms:tert-butyl 4-((3-(2-(methylthio)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-((3-(2-(methylthio)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of tert-butyl 4-((3-(2-(methylthio)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-((3-(2-(methylthio)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

: 1386398-83-9
6-chloro-3-(2-methylsulfanyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

: 144222-22-0
tert-butyl 4-(aminomethyl)piperidine-1-carboxylate

: 1386398-91-9
4-{[3-(2-methylsulfanyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In isopropyl alcohol; for 15h; Reflux;

Reference yield:

: 1074-68-6
4-formyl-2-(methylthio)pyrimidine

: 1386398-91-9
4-{[3-(2-methylsulfanyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -30 °C

1.2: 1 h / 0 °C

2.1: manganese(IV) oxide / dichloromethane; methanol / 16 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; hydrazine hydrate / tetrahydrofuran / 4 h / 50 °C

4.1: triethylamine / isopropyl alcohol / 15 h / Reflux

With manganese(IV) oxide; isopropylmagnesium chloride; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 1386398-84-0
(2,4-dichloro-pyrimidin-5-yl)-(2-methylsulfanyl-pyrimidin-4-yl)-methanol

: 1386398-91-9
4-{[3-(2-methylsulfanyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: manganese(IV) oxide / dichloromethane; methanol / 16 h / Reflux

2: N-ethyl-N,N-diisopropylamine; hydrazine hydrate / tetrahydrofuran / 4 h / 50 °C

3: triethylamine / isopropyl alcohol / 15 h / Reflux

With manganese(IV) oxide; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;