alpha-AMino-4-fluorophenyl-acetic acid Methyl ester

Base Information

• Chemical Name: alpha-AMino-4-fluorophenyl-acetic acid Methyl ester
• CAS No.: 42718-13-8
• Molecular Formula: C9H10FNO2
• Molecular Weight: 183.182
• Mol file: 42718-13-8.mol

Synonyms:alpha-AMino-4-fluorophenyl-acetic acid Methyl ester;Methyl 2-aMino-2-(4-fluorophenyl)acetate;2-(4-Fluoro-phenyl)-DL-glycine Methyl ester HCl

Chemical Property of alpha-AMino-4-fluorophenyl-acetic acid Methyl ester

Chemical Property:

• PSA: 52.32000
• LogP: 1.69880

Purity/Quality:

95% ^*data from raw suppliers

Methyl 2-amino-2-(4-fluorophenyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of alpha-AMino-4-fluorophenyl-acetic acid Methyl ester

There total 7 articles about alpha-AMino-4-fluorophenyl-acetic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

→ racemic α-amino-4-fluorobenzeneacetic acid methyl ester + α-amino-4-fluorobenzeneacetic acid methyl ester (42718-13-8,170902-76-8)

Guidance literature:

Reference yield:

methanol (67-56-1) + (2RS)-N-(p-fluorophenyl)glycine (7292-73-1) → α-amino-4-fluorobenzeneacetic acid methyl ester (42718-13-8,170902-76-8)

Guidance literature:

With hydrogenchloride; at 0 - 20 ℃; for 18h;

Reference yield:

C9H8FNO3 → α-amino-4-fluorobenzeneacetic acid methyl ester (42718-13-8,170902-76-8)

Guidance literature:

With formic acid; zinc; In methanol; water; at 0 - 20 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.tet.2016.07.046

upstream raw materials:

methanol

(2RS)-N-(p-fluorophenyl)glycine

1-(4-fluorophenyl)ethanone

methyl (p-fluorobenzoyl)formate

Downstream raw materials:

(2S,3S,3aS,9bS)-3-ethyl-2-methyl-2-(4-fluorophenyl)-1,2,3,3a,4,9b-hexahydrochromeno[4,3-b]pyrrole-2,3-dicarboxylate

methyl 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetate

N-[carboxy(4-fluorophenyl)methyl]-2-(2,4-dichlorophenoxy)propanamide

Refernces

• 1、 -. "NOVEL AMINOPEPTIDASE INHIBITORS AND METHODS OF USE". Paragraph 0047. . Retrieved 2017/02/09.
• 2、 Fan, Dongyang,Lu, Jian,Liu, Yang,Zhang, Zhenfeng,Liu, Yangang,Zhang, Wanbin. "Rh-catalyzed asymmetric hydrogenation of racemic aldimines via dynamic kinetic resolution". . p. 5541 - 5547. Retrieved 2016/08/05.