tert-butyl 5-bromothiazol-2-yl(methyl)carbamate

Base Information

• Chemical Name: tert-butyl 5-bromothiazol-2-yl(methyl)carbamate
• CAS No.: 1314095-64-1
• Molecular Formula: C₉H₁₃BrN₂O₂S
• Molecular Weight: 293.184
• Mol file: 1314095-64-1.mol

Synonyms:tert-butyl 5-bromothiazol-2-yl(methyl)carbamate;(5-Bromo-thiazol-2-yl)-methyl-carbamic acid tert-butyl ester

Chemical Property of tert-butyl 5-bromothiazol-2-yl(methyl)carbamate

Chemical Property:

• Boiling Point: 319.6±34.0 °C(Predicted)
• PKA: 1.96±0.10(Predicted)
• Density: 1.496±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(5-bromothiazol-2-yl)(methyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 5-bromothiazol-2-yl(methyl)carbamate

There total 3 articles about tert-butyl 5-bromothiazol-2-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(N-tert-butoxycarbonyl-N-methyl-amino)-thiazole (479198-74-8) → tert-butyl 5-bromothiazol-2-yl(methyl)carbamate (1314095-64-1)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; at 5 - 20 ℃; for 2h;

Reference yield:

tert-butyl 1,3-thiazole-2-yl-carbamate (170961-15-6) → tert-butyl 5-bromothiazol-2-yl(methyl)carbamate (1314095-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 5 - 20 °C

2: N-Bromosuccinimide / tetrahydrofuran / 2 h / 5 - 20 °C

With N-Bromosuccinimide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-bromothiazol-2-yl(methyl)carbamate (1314095-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 16 h / 20 °C

2: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 5 - 20 °C

3: N-Bromosuccinimide / tetrahydrofuran / 2 h / 5 - 20 °C

With N-Bromosuccinimide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

tert-butyl 1,3-thiazole-2-yl-carbamate

di-tert-butyl dicarbonate

2-(N-tert-butoxycarbonyl-N-methyl-amino)-thiazole