Oxo-(1-pyridin-3-yl-1H-indol-3-yl)-acetic acid methyl ester

Base Information

Chemical Name:Oxo-(1-pyridin-3-yl-1H-indol-3-yl)-acetic acid methyl ester
CAS No.:436159-86-3
Molecular Formula:C16H12N2O3
Molecular Weight:280.283
Hs Code.:
Mol file:436159-86-3.mol

Synonyms:Oxo-(1-pyridin-3-yl-1H-indol-3-yl)-acetic acid methyl ester

Suppliers and Price of Oxo-(1-pyridin-3-yl-1H-indol-3-yl)-acetic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Oxo-(1-pyridin-3-yl-1H-indol-3-yl)-acetic acid methyl ester

Chemical Property:

PSA：61.19000
LogP:2.38120

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Oxo-(1-pyridin-3-yl-1H-indol-3-yl)-acetic acid methyl ester

There total 7 articles about Oxo-(1-pyridin-3-yl-1H-indol-3-yl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 79-37-8
oxalyl dichloride

: 25700-23-6
1-(pyridin-3-yl)-1H-indole

: 436159-86-3
oxo-(1-pyridin-3-yl-1H-indol-3-yl)-acetic acid methyl ester

Guidance literature:: oxalyl dichloride; 1-(pyridin-3-yl)-1H-indole; In dichloromethane; at 0 ℃; for 16h;

With sodium methylate; In methanol; dichloromethane; at -65 ℃;

Reference yield: 65.0%

: 79-37-8
oxalyl dichloride

: 124-41-4
sodium methylate

: 25700-23-6
1-(pyridin-3-yl)-1H-indole

: 436159-86-3
oxo-(1-pyridin-3-yl-1H-indol-3-yl)-acetic acid methyl ester

Guidance literature:: oxalyl dichloride; 1-(pyridin-3-yl)-1H-indole; In dichloromethane; at 20 ℃; for 16h;

sodium methylate; In methanol; dichloromethane; at -65 - 20 ℃; for 1h;

Reference yield:

: 120-72-9
indole

: 436159-86-3
oxo-(1-pyridin-3-yl-1H-indol-3-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / K₂CO₃; CuO / dimethylformamide / 16 h / Heating

2: CH₂Cl₂ / 16 h / 20 °C

3: 0.73 g / methanol / 1 h / 20 °C

With potassium carbonate; copper(II) oxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049478u