N-[(1R,2R)-1,2-Diphenyl-2-(2-(4-Methylbenzyloxy)ethylaMino)-ethyl]-4-Methylbenzene sulfonaMide(chloro)rutheniuM(II) (R,R)-Ts-DENEB 1333981-84-2

Base Information

• Chemical Name: N-[(1R,2R)-1,2-Diphenyl-2-(2-(4-Methylbenzyloxy)ethylaMino)-ethyl]-4-Methylbenzene sulfonaMide(chloro)rutheniuM(II) (R,R)-Ts-DENEB 1333981-84-2
• CAS No.: 1333981-84-2
• Molecular Formula: C₃₁H₃₃ClN₂O₃RuS
• Molecular Weight: 650.204
• Mol file: 1333981-84-2.mol

Synonyms:N-[(1R,2R)-1,2-Diphenyl-2-(2-(4-Methylbenzyloxy)ethylaMino)-ethyl]-4-Methylbenzene sulfonaMide(chloro)rutheniuM(II) (R,R)-Ts-DENEB 1333981-84-2;(R,R)-Ts-DENEB(regR);(R,R)-Ts-DENEB;N-[(1R,2R)-1,2-Diphenyl-2-(2-(4-Methylbenzyloxy)ethylaMino)-ethyl]-4-Methylbenzene sulfonaMide(chloro)rutheniuM(II);Chloro{N-[(1R,2R)-1,2-diphenyl-2-(2-(4-methylbenzyloxy)ethylamino)-ethyl]-4-methylbenzene sulfonamide(chloro)ruthenium(II)

Chemical Property of N-[(1R,2R)-1,2-Diphenyl-2-(2-(4-Methylbenzyloxy)ethylaMino)-ethyl]-4-Methylbenzene sulfonaMide(chloro)rutheniuM(II) (R,R)-Ts-DENEB 1333981-84-2

Chemical Property:

• PSA: 58.23000
• LogP: 7.43150
• Sensitive.: air sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R,R)-Ts-DENEB ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R,R)-Ts-DENEB (CAS# 1333981-84-2) is a catalyst used in asymmetric hydrogen transfer reactions, such as in the synthesis of 2-(1,2,3,4-tetrahydro-1-isoquinolyl)ethanol derivatives. (R,R)-Ts-DENEB is used to form hydrogen carrier systems, where the catalytic dehydrogenative coupling of methanol and 1,2-diamine is used to generate H2 without the production of CO2.

Technology Process of N-[(1R,2R)-1,2-Diphenyl-2-(2-(4-Methylbenzyloxy)ethylaMino)-ethyl]-4-Methylbenzene sulfonaMide(chloro)rutheniuM(II) (R,R)-Ts-DENEB 1333981-84-2

There total 2 articles about N-[(1R,2R)-1,2-Diphenyl-2-(2-(4-Methylbenzyloxy)ethylaMino)-ethyl]-4-Methylbenzene sulfonaMide(chloro)rutheniuM(II) (R,R)-Ts-DENEB 1333981-84-2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N-((1R,2R)-2-(2-hydroxyethylamino)-1,2-diphenylethyl)-4-methylbenzenesulfonamide (1242103-61-2) + [RuCl2(1-(bromomethyl)-4-methylbenzene)]2 (1333982-07-2) → N-[(1R,2R)-1,2-diphenyl-2-(2-(4-methylbenzyloxy)ethylamino)ethyl]-4-methylbenzenesulfonamide(chloro)ruthenium(II) (1333981-84-2,1384974-37-1)

Guidance literature:

N-((1R,2R)-2-(2-hydroxyethylamino)-1,2-diphenylethyl)-4-methylbenzenesulfonamide; [RuCl₂(1-(bromomethyl)-4-methylbenzene)]2; With triethylbenzylammonium iodide; potassium hydroxide; In dichloromethane; water; at 35 ℃; for 3h;

With hydrogenchloride; In dichloromethane; water; for 0.5h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

2-(prop-2-ynyloxy)ethanol (3973-18-0) + ruthenium(III) chloride trihydrate + p-toluenesulfonyl chloride (98-59-9) + (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine (144222-34-4) + isoprene (78-79-5,9003-31-0) → RuCl((R,R)-O-HT-Tsdpen) (1360897-61-5) + N-[(1R,2R)-1,2-diphenyl-2-(2-(4-methylbenzyloxy)ethylamino)ethyl]-4-methylbenzenesulfonamide(chloro)ruthenium(II) (1333981-84-2,1384974-37-1)

Guidance literature:

2-(prop-2-ynyloxy)ethanol; isoprene; With zinc(II) iodide; zinc; 1,2-bis-(diphenylphosphino)ethane; cobalt(II) bromide; In tetrahydrofuran; at 35 ℃; for 1h; Inert atmosphere;

p-toluenesulfonyl chloride; With 1-methyl-1H-imidazole; triethylamine; In toluene; at 20 ℃; for 1h; Cooling with ice;

ruthenium(III) chloride trihydrate; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine;

Reference yield: 99.0%

N-[(1R,2R)-1,2-diphenyl-2-(2-(4-methylbenzyloxy)ethylamino)ethyl]-4-methylbenzenesulfonamide(chloro)ruthenium(II) (1333981-84-2,1384974-37-1) + silver trifluoroacetate (2966-50-9) → Ru(CF3COO)((R,R)-O-HT-Tsdpen)

Guidance literature:

In methanol; dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

2-(prop-2-ynyloxy)ethanol

p-toluenesulfonyl chloride

(R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine

isoprene

Downstream raw materials:

RuCl((R,R)-O-HT-Tsdpen)

Ru((R,R)-O-HT-Tsdpen)

Refernces