Welcome to LookChem.com Sign In|Join Free

CAS

  • or

3973-18-0

Post Buying Request

3973-18-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

3973-18-0 Usage

Description

Propargyl-PEG2-alcohol has propargyl and alcohol end groups. The propargyl can participate in copper-catalyzed Click Chemistry reactions with azides.

Chemical Properties

Propynol ethoxylate(PME) is a clear colourless to pale yellow oil.

Uses

Propynol Ethoxylate is an intermediate and it is shown to be used in the design and synthesis of a tag-free chemical probe for photoafiinity labeling.

Check Digit Verification of cas no

The CAS Registry Mumber 3973-18-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,7 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3973-18:
(6*3)+(5*9)+(4*7)+(3*3)+(2*1)+(1*8)=110
110 % 10 = 0
So 3973-18-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H8O2/c1-2-4-7-5-3-6/h1,6H,3-5H2

3973-18-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Propynol Ethoxylate

1.2 Other means of identification

Product number -
Other names 2-(Prop-2-yn-1-yloxy)ethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3973-18-0 SDS

3973-18-0Synthetic route

ethylene glycol
107-21-1

ethylene glycol

propargyl bromide
106-96-7

propargyl bromide

2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

Conditions
ConditionsYield
Stage #1: ethylene glycol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;
Stage #2: propargyl bromide at 0 - 50℃;
80%
Stage #1: ethylene glycol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;
Stage #2: propargyl bromide In N,N-dimethyl-formamide; mineral oil at 0 - 50℃;
80%
With potassium hydroxide In water; toluene at 4 - 20℃; for 48h;76%
propynoic aldehyde ethyleneglycol acetal
18938-38-0

propynoic aldehyde ethyleneglycol acetal

2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

Conditions
ConditionsYield
With benzo[1,3,2]dioxaborole In benzene at 50℃;67%
ethylene glycol vinyl propargyl diether
14846-79-8

ethylene glycol vinyl propargyl diether

2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

Conditions
ConditionsYield
(hydrolysis);
ethylene glycol
107-21-1

ethylene glycol

2-propynyl chloride
624-65-7

2-propynyl chloride

2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

Conditions
ConditionsYield
(i) Na, (ii) /BRN= 506005/; Multistep reaction;
sodium propargylate
39115-81-6

sodium propargylate

2-chloro-ethanol
107-07-3

2-chloro-ethanol

2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

tert-butyl dimethyl(2-(prop-2-yn-1-yloxy)ethoxy)silane
339531-56-5

tert-butyl dimethyl(2-(prop-2-yn-1-yloxy)ethoxy)silane

2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

Conditions
ConditionsYield
With hydrogen fluoride In water; acetonitrile at 0℃; for 3h;
propargyl bromide
106-96-7

propargyl bromide

2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

Conditions
ConditionsYield
In diethyl ether; water; ethylene glycol; toluene
pent-1-yn-5-ol
5390-04-5

pent-1-yn-5-ol

2-bromoethanol
540-51-2

2-bromoethanol

2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 60℃; Inert atmosphere;
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

2‐(prop‐2‐yn‐1‐yloxy)ethyl methanesulfonate

2‐(prop‐2‐yn‐1‐yloxy)ethyl methanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;99%
With triethylamine In diethyl ether at 0 - 20℃; for 1.5h; Inert atmosphere;91%
With triethylamine In diethyl ether at 0℃;
With triethylamine In diethyl ether at 0℃;
With triethylamine In dichloromethane at 0℃; for 0.166667h; Inert atmosphere; Schlenk technique;
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

2,3,3,3-tetrafluoropropionic acid
359-49-9

2,3,3,3-tetrafluoropropionic acid

C8H8F4O3

C8H8F4O3

Conditions
ConditionsYield
With phosphomolybdic acid; toluene-4-sulfonic acid In 5,5-dimethyl-1,3-cyclohexadiene at 140 - 145℃; for 8h; Temperature; Reagent/catalyst;99%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

ethanol-2-(2-propyn-1-yloxy) 1-(4-methylbenzenesulfonate)
145916-41-2

ethanol-2-(2-propyn-1-yloxy) 1-(4-methylbenzenesulfonate)

Conditions
ConditionsYield
With pyridine at 0℃; for 4h;95%
With dmap; triethylamine In dichloromethane at 20℃; for 60h; Inert atmosphere;89%
With pyridine Inert atmosphere;85%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

3-(2-bromoethyloxy)prop-1-yne
18668-74-1

3-(2-bromoethyloxy)prop-1-yne

Conditions
ConditionsYield
With carbon tetrabromide; triphenylphosphine In dichloromethane; acetonitrile at 0℃; for 0.5h;92%
With phosphorus tribromide In pyridine at -15℃;70%
With pyridine; dibromotriphenoxyphosphorane
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

4-bromobenzenesulfonyl chloride
98-58-8

4-bromobenzenesulfonyl chloride

2-(prop-2-yn-1-yloxy)ethyl 4-bromobenzenesulfonate
1622092-44-7

2-(prop-2-yn-1-yloxy)ethyl 4-bromobenzenesulfonate

Conditions
ConditionsYield
With potassium hydroxide In diethyl ether at 0 - 20℃; for 5h; Inert atmosphere;92%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

C42H68N3O10(1-)*Na(1+)

C42H68N3O10(1-)*Na(1+)

C47H76N3O12(1-)*Na(1+)

C47H76N3O12(1-)*Na(1+)

Conditions
ConditionsYield
With copper(II) sulfate; sodium L-ascorbate In tetrahydrofuran; water at 20℃; Inert atmosphere;91%
With copper(II) sulfate; sodium L-ascorbate In tetrahydrofuran at 20℃; Inert atmosphere;91%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

3-(2-iodoethyloxy)prop-1-yne
164118-56-3

3-(2-iodoethyloxy)prop-1-yne

Conditions
ConditionsYield
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 0 - 20℃; for 2h;91%
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 20℃; Inert atmosphere;
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

boric acid
11113-50-1

boric acid

(HCCCH2OCH2CH2O)3B
223576-65-6

(HCCCH2OCH2CH2O)3B

Conditions
ConditionsYield
In benzene byproducts: H2O; B-compd. to alcohol molar ratio 1:4, boiling (6-14 h) to the end of water distillation off; benzene removing in vacuum; elem. anal.;90%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

2-(1H-pyrrol-1-yl)aniline
6025-60-1

2-(1H-pyrrol-1-yl)aniline

2-((4,5-dihydro-4-methylpyrrolo[1,2-a]quinoxalin-4-yl)methoxy)ethanol
1176667-04-1

2-((4,5-dihydro-4-methylpyrrolo[1,2-a]quinoxalin-4-yl)methoxy)ethanol

Conditions
ConditionsYield
With platinum(II) bromde In methanol at 80℃; for 12h; Markownikoff hydroamination-hydroarylation; Inert atmosphere;88%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

C11H21BO4

C11H21BO4

Conditions
ConditionsYield
Stage #1: bis(pinacol)diborane With methanol; copper(II) bis(trifluoromethanesulfonate); 2,6-bis(pyrazole)pyridine; sodium t-butanolate In acetonitrile for 0.5h; Inert atmosphere; Schlenk technique;
Stage #2: 2-(prop-2-ynyloxy)ethanol In acetonitrile at 50℃; for 3h; Inert atmosphere; Schlenk technique; regioselective reaction;
88%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

anthranilic acid amide
28144-70-9

anthranilic acid amide

2-[(2-hydroxyethoxy)methyl]-2-methyl-1,2,3,4-tetrahydro-4-quinazolinone
1208003-47-7

2-[(2-hydroxyethoxy)methyl]-2-methyl-1,2,3,4-tetrahydro-4-quinazolinone

Conditions
ConditionsYield
With platinum(II) bromde In methanol at 80℃; for 24h; Markownikoff double hydroamination; Inert atmosphere;87%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

2-(2-(prop-2-yn-1-yloxy)ethoxy)tetrahydro-2H-pyran
119096-95-6

2-(2-(prop-2-yn-1-yloxy)ethoxy)tetrahydro-2H-pyran

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane at 0 - 20℃; for 4h;87%
With pyridinium p-toluenesulfonate In dichloromethane at 0℃;44%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

hexachlorocyclopentadiene
77-47-4

hexachlorocyclopentadiene

2-(1,4,5,6,7,7-Hexachloro-bicyclo[2.2.1]hepta-2,5-dien-2-ylmethoxy)-ethanol
78927-95-4

2-(1,4,5,6,7,7-Hexachloro-bicyclo[2.2.1]hepta-2,5-dien-2-ylmethoxy)-ethanol

Conditions
ConditionsYield
With hydroquinone at 150 - 155℃; for 8h;86%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

benzyl chloride
100-44-7

benzyl chloride

({[2-(2-propyn-1-yloxy)ethyl]oxy}methyl)benzene
219716-49-1

({[2-(2-propyn-1-yloxy)ethyl]oxy}methyl)benzene

Conditions
ConditionsYield
Stage #1: 2-(prop-2-ynyloxy)ethanol With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In acetonitrile at 50℃; for 0.5h;
Stage #2: benzyl chloride In acetonitrile at 50℃; for 2h;
85%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

buta-1,3-diene
106-99-0

buta-1,3-diene

2-(cyclohexa-1,4-dienylmethoxy)ethanol
1404469-82-4

2-(cyclohexa-1,4-dienylmethoxy)ethanol

Conditions
ConditionsYield
With tetrabutylammonium borohydride; 1,2-bis-(diphenylphosphino)ethane; cobalt(II) bromide; zinc(II) iodide; zinc In dichloromethane; toluene at 45℃; for 1h;85%
ethyl 3-benzamido-2-oxo-6-(trifluoromethyl)-2H-pyran-5-carboxylate

ethyl 3-benzamido-2-oxo-6-(trifluoromethyl)-2H-pyran-5-carboxylate

2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

ethyl 5-benzamido-4-((2-hydroxyethoxy)methyl)-2-(trifluoromethyl)benzoate

ethyl 5-benzamido-4-((2-hydroxyethoxy)methyl)-2-(trifluoromethyl)benzoate

Conditions
ConditionsYield
In neat (no solvent) at 150℃; Diels-Alder Cycloaddition; Microwave irradiation; regioselective reaction;84%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

C44H71N3O12

C44H71N3O12

C49H79N3O14

C49H79N3O14

Conditions
ConditionsYield
With copper(II) sulfate; sodium L-ascorbate In water; tert-butyl alcohol at 4 - 55℃; for 24h; Inert atmosphere;83%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

cyclopenta-1,3-diene
542-92-7

cyclopenta-1,3-diene

2-(Bicyclo[2.2.1]hepta-2,5-dien-2-ylmethoxy)-ethanol
69392-36-5

2-(Bicyclo[2.2.1]hepta-2,5-dien-2-ylmethoxy)-ethanol

Conditions
ConditionsYield
With hydroquinone at 170 - 175℃; for 14h;82.2%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

4-chloro-2-nitroiodobenzene
5446-05-9

4-chloro-2-nitroiodobenzene

C11H10ClNO4
1344728-37-5

C11H10ClNO4

Conditions
ConditionsYield
Stage #1: 2-(prop-2-ynyloxy)ethanol; 4-chloro-2-nitroiodobenzene With bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine In N,N-dimethyl-formamide for 0.5h; Sonogashira coupling; Inert atmosphere;
Stage #2: With copper(l) iodide In N,N-dimethyl-formamide at 20℃; for 5.16667h; Sonogashira coupling; Inert atmosphere;
82%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

Dimethylphenylsilane
766-77-8

Dimethylphenylsilane

(E)-2-{3-[dimethyl(phenyl)silyl]allyloxy}ethanol

(E)-2-{3-[dimethyl(phenyl)silyl]allyloxy}ethanol

Conditions
ConditionsYield
With C60H84Cl2O6P2PtS2(2-)*2Na(1+) In water at 60℃; for 6h; Inert atmosphere; Green chemistry; stereoselective reaction;81%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

cyclopenta-1,3-diene
542-92-7

cyclopenta-1,3-diene

A

2-(Bicyclo[2.2.1]hepta-2,5-dien-2-ylmethoxy)-ethanol
69392-36-5

2-(Bicyclo[2.2.1]hepta-2,5-dien-2-ylmethoxy)-ethanol

C15H20O2
69392-39-8

C15H20O2

Conditions
ConditionsYield
With hydroquinone at 180 - 185℃; for 14h;A n/a
B 80.5%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

propargyl bromide
106-96-7

propargyl bromide

α,ω-bis(O-propargyl)ethylene glycol
40842-04-4

α,ω-bis(O-propargyl)ethylene glycol

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide at 50 - 60℃; for 3h;80.2%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

2-(prop-2-yn-1-yloxy)-1-dichlorophosphite

2-(prop-2-yn-1-yloxy)-1-dichlorophosphite

Conditions
ConditionsYield
With phosphorus trichloride for 5h; Cooling; Heating;80.2%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

diphenylchloromethane
90-99-3

diphenylchloromethane

{phenyl[2-(prop-2-ynyloxy)ethoxy]methyl}benzene

{phenyl[2-(prop-2-ynyloxy)ethoxy]methyl}benzene

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride at -30 - 50℃;80%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

2,5-dioxopyrrolidin-1-yl 2-(prop-2-yn-1-yloxy)ethyl carbonate

2,5-dioxopyrrolidin-1-yl 2-(prop-2-yn-1-yloxy)ethyl carbonate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 40℃; for 2h;80%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

3,4-dinitrobenzoic acid
528-45-0

3,4-dinitrobenzoic acid

2-(prop-2-yn-1-yloxy)ethyl 3,4-dinitrobenzoate

2-(prop-2-yn-1-yloxy)ethyl 3,4-dinitrobenzoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 5h; Mitsunobu Displacement; Inert atmosphere;79%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

tert-butyl dimethyl(2-(prop-2-yn-1-yloxy)ethoxy)silane
339531-56-5

tert-butyl dimethyl(2-(prop-2-yn-1-yloxy)ethoxy)silane

Conditions
ConditionsYield
With pyridine; dmap In dichloromethane78%
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 12h;78%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

ethylene glycol monoallyl ether
111-45-5

ethylene glycol monoallyl ether

Conditions
ConditionsYield
Stage #1: 2-(prop-2-ynyloxy)ethanol With lithium aluminium tetrahydride In 1,4-dioxane at -5℃; for 6h; Reflux;
Stage #2: With water; sodium hydroxide In 1,4-dioxane at 0℃;
78%
2-(prop-2-ynyloxy)ethanol
3973-18-0

2-(prop-2-ynyloxy)ethanol

N-(2-aminophenyl)indole
473918-48-8

N-(2-aminophenyl)indole

C19H20N2O2

C19H20N2O2

Conditions
ConditionsYield
With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate In methanol at 60℃; for 12h; Inert atmosphere;77%

3973-18-0Relevant articles and documents

Fluorogenic tagging of peptides via Cys residues using thiol-specific vinyl sulfone affinity tags

Cserép, Gergely B.,Baranyai, Zsuzsa,Komáromy, Dávid,Horváti, Kata,Bosze, Szilvia,Kele, Péter

, p. 5961 - 5965 (2014)

Fluorescent tagging of Cys-containing peptides is presented herein. The procedure follows a two-step sequential reaction scheme using thiol specific bifunctional chemical reporters and fluorogenic labels. Vinyl-sulfone bearing chemical reporters have been synthesized and demonstrated to selectively modify cysteine under physiological conditions in the presence of other nucleophilic amino acids. Bifunctional chemical reporters decorated with a terminal alkyne moiety, suitable for modification with azide containing fluorogenic labels were also synthesized. Such fluorogenic (turn on) labels in combination with these new vinyl-sulfone tags can be used generally in fluorescent modulation schemes of thiol-bearing biomolecules.

-

, p. 1444 - 1451 (2018)

-

BRANCHED MOIETY FOR USE IN CONJUGATES

-

Page/Page column 38, (2021/04/30)

A tri-functional linker moiety: formula (I), where X and Y are linking chains, and its use for preparing dual-mechanistic drug conjugates, preferably in a site-specific manner.

Novel camptothecin derivative, and preparation method and application thereof

-

Paragraph 0087-0088; 0095-0096, (2020/03/12)

The invention relates to a novel camptothecin derivative and application thereof, a tumor cell growth inhibitor, a ternary complex, and a method for improving the solubility of the camptothecin derivative. The camptothecin derivative is formed by modifying a substance represented by formula I through glycosylated triazole in the position R3. In a structural formula represented by the formula I, R1represents H, alkyl of C1-10, deuterated alkyl of the C1-10, or halogenated alkyl of the C1-10; R2 represents H, CH2N(CH3)2 or CH2N(CD3)2; R4 represents H, and X represents N, O or S; L represents polypeptide, C1-20 linear alkyl or a derivative thereof, a C1-20 linear or branched acyl derivative, or C2-100 ethylene glycol or a derivative thereof. The camptothecin derivative has high solubility, prepared anticancer drugs have the advantages of wide anticancer spectrum and high safety, and the in-vivo anticancer activity is superior to that of irinotecan hydrochloride.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 3973-18-0