Methyl 1-Acetyl-6-broMo-1H-indazole-4-carboxylate

Base Information

• Chemical Name: Methyl 1-Acetyl-6-broMo-1H-indazole-4-carboxylate
• CAS No.: 1346597-55-4
• Molecular Formula: C₁₁H₉BrN₂O₃
• Molecular Weight: 297.108
• Hs Code.: 2933990090
• Mol file: 1346597-55-4.mol

Synonyms:Methyl 1-Acetyl-6-broMo-1H-indazole-4-carboxylate;1H-Indazole-4-carboxylic acid, 1-acetyl-6-broMo-, Methyl ester

Chemical Property of Methyl 1-Acetyl-6-broMo-1H-indazole-4-carboxylate

Chemical Property:

• Boiling Point: 425.6±48.0 °C(Predicted)
• PKA: -4.29±0.30(Predicted)
• PSA: 61.19000
• Density: 1 +-.0.1 g/cm3(Predicted)
• LogP: 2.24550

Purity/Quality:

97% ^*data from raw suppliers

Methyl1-Acetyl-6-bromo-1H-indazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-Acetyl-6-broMo-1H-indazole-4-carboxylate

There total 4 articles about Methyl 1-Acetyl-6-broMo-1H-indazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

2-methyl-3-amino-5-bromobenzoic acid methyl ester (1000342-11-9) + acetic anhydride (108-24-7) → methyl 1-acetyl-6-bromo-1H-indazole-4-carboxylate (1346597-55-4)

Guidance literature:

2-methyl-3-amino-5-bromobenzoic acid methyl ester; acetic anhydride; With potassium acetate; In chloroform; at 20 ℃; for 12h;

With tert.-butylnitrite; 18-crown-6 ether; In chloroform; at 65 ℃; for 3h;

Reference yield:

5-bromo-2-methyl-3-nitro-benzoic acid (107650-20-4) → methyl 1-acetyl-6-bromo-1H-indazole-4-carboxylate (1346597-55-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: potassium acetate / chloroform / 12 h / 20 °C

3.2: 3 h / 65 °C

With potassium acetate; iron; sodium carbonate; ammonium chloride; In ethanol; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

5-bromo-2-methyl-3-nitrobenzoic acid methyl ester (220514-28-3) → methyl 1-acetyl-6-bromo-1H-indazole-4-carboxylate (1346597-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

2.1: potassium acetate / chloroform / 12 h / 20 °C

2.2: 3 h / 65 °C

With potassium acetate; iron; ammonium chloride; In ethanol; chloroform; water;

upstream raw materials:

2-methyl-3-amino-5-bromobenzoic acid methyl ester

acetic anhydride

5-bromo-2-methyl-3-nitro-benzoic acid

5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

Downstream raw materials:

C₂₂H₂₄N₂O₄

1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-hydroxypropoxy)phenyl)-1H-indazole-4-carboxamide

methyl 1-cyclopentyl-6-(4-(3-hydroxypropoxy)phenyl)-1H-indazole-4-carboxylate

methyl 1-cyclopentyl-6-(4-hydroxyphenyl)-1H-indazole-4-carboxylate

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