Methyl 6-broMo-l-(l- Methylethyl)-lH-indazole-4-carboxylate

Base Information

• Chemical Name: Methyl 6-broMo-l-(l- Methylethyl)-lH-indazole-4-carboxylate
• CAS No.: 1346702-52-0
• Molecular Formula: C₁₂H₁₃BrN₂O₂
• Molecular Weight: 297.151
• Hs Code.: 2933998090
• Mol file: 1346702-52-0.mol

Synonyms:Methyl 6-broMo-l-(l- Methylethyl)-lH-indazole-4-carboxylate;6-Bromo-1-(1-methylethyl)-1H-indazole-4-carboxylic acid methyl ester;Methyl 6-bromo-1-(propan-2-yl)-1H-indazole-4-carboxylate;Methyl 6-bromo-1-isopropyl-1H-indazole-4-carboxylate

Chemical Property of Methyl 6-broMo-l-(l- Methylethyl)-lH-indazole-4-carboxylate

Chemical Property:

• Boiling Point: 372.9±22.0 °C(Predicted)
• PKA: -0.89±0.30(Predicted)
• PSA: 44.12000
• Density: 1.50±0.1 g/cm3(Predicted)
• LogP: 3.16630

Purity/Quality:

99%, ^*data from raw suppliers

methyl6-bromo-1-(propan-2-yl)-1H-indazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-broMo-l-(l- Methylethyl)-lH-indazole-4-carboxylate

There total 8 articles about Methyl 6-broMo-l-(l- Methylethyl)-lH-indazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

methyl 6-bromo-1H-indazole-4-carboxylate (885518-49-0) + isopropyl bromide (75-26-3) → methyl 6-bromo-2-(1-methylethyl)-2H-indazole-4-carboxylate (1346702-53-1) + methyl 6-bromo-1-(1-methylethyl)-1H-indazole-4-carboxylate (1346702-52-0)

Guidance literature:

With caesium carbonate; In acetonitrile;

DOI:10.1021/acs.jmedchem.6b00855

Reference yield: 32.6%

2-iodo-propane (75-30-9) + methyl 6-bromo-1H-indazole-4-carboxylate (885518-49-0) → methyl 6-bromo-1-(1-methylethyl)-1H-indazole-4-carboxylate (1346702-52-0)

Guidance literature:

With caesium carbonate; In acetonitrile; at 90 ℃; for 2h;

Reference yield: 18.0%

→ methyl 6-bromo-1-(1-methylethyl)-1H-indazole-4-carboxylate (1346702-52-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

methyl 6-bromo-1H-indazole-4-carboxylate

isopropyl bromide

2-iodo-propane

5-bromo-2-methyl-3-nitro-benzoic acid

Downstream raw materials:

GSK343

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide

N-((4-cyclohexyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-cyclopropyl-1-isopropyl-1H-indazole-4-carboxamide

6-bromo-N-((4-cyclohexyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-1H-indazole-4-carboxamide

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