Cebranopadol hemicitrate

Base Information

• Chemical Name: Cebranopadol hemicitrate
• CAS No.: 863513-92-2
• Molecular Formula: 0C₆H₈O₇*C₂₄H₂₇FN₂O
• Molecular Weight: 474.552
• Mol file: 863513-92-2.mol

Synonyms:Cebranopadol hemicitrate;(1alpha,4beta)-6'-Fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine 2-hydroxy-1,2,3-propanetricarboxylate (2:1);Difelikefalin

Chemical Property of Cebranopadol hemicitrate

Chemical Property:

• PSA: 188.65000
• LogP: 8.96370

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cebranopadol hemicitrate

There total 3 articles about Cebranopadol hemicitrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1s,4s)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine (863513-93-3) + citric acid (77-92-9,906507-37-7) → C24H27FN2O*0.5C6H8O7 (863513-92-2)

Guidance literature:

In ethanol; Heating;

Reference yield:

(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine (863513-91-1) + citric acid (77-92-9,906507-37-7) → trans-6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine hemicitrate (863513-92-2)

Guidance literature:

In ethanol; at 5 ℃; Heating;

DOI:10.1021/ml500117c

Reference yield:

(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine + citric acid (77-92-9,906507-37-7) → 1,1-(3-dimethylamino-3-phenyl-pentamethylen)-6-fluoro-1,3,4,9-tetrahydropyrano-[3,4-b]-indol hemicitrate (863513-92-2)

Guidance literature:

In ethanol; at 5 ℃; for 2.25h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

citric acid

(1s,4s)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine

(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 863513-92-2 Cebranopadol hemicitrate

Send

Send

Metric Ton KG G Pound L ML

Send

Send