863513-93-3

Basic information

• Product Name: Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-aMine, 6'-fluoro-4',9'-dihydro-N,N-diMethyl-4-phenyl-, cis- (9CI)
• Synonyms: Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-aMine, 6'-fluoro-4',9'-dihydro-N,N-diMethyl-4-phenyl-, cis- (9CI);Cebranopadol ((1α,4α)stereoisomer)
• CAS NO: 863513-93-3
• Molecular Formula: C₂₄H₂₇FN₂O
• Molecular Weight: 378.4823832
• Mol File: 863513-93-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-aMine, 6'-fluoro-4',9'-dihydro-N,N-diMethyl-4-phenyl-, cis- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-aMine, 6'-fluoro-4',9'-dihydro-N,N-diMethyl-4-phenyl-, cis- (9CI)(863513-93-3)
• EPA Substance Registry System: Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-aMine, 6'-fluoro-4',9'-dihydro-N,N-diMethyl-4-phenyl-, cis- (9CI)(863513-93-3)

Safety Data

• Hazardous Substances Data: 863513-93-3(Hazardous Substances Data)

Upstream product

• 65619-19-4 4-dimethylamino-4-phenylcyclohexanone, ethylene ketal hydrochloride 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 65619-20-7 4-dimethylamino-4-phenylcyclohexanone 
• 101349-12-6 2-(5-fluoro-1H-indol-3-yl)ethanol 

Downstream Products

• 863513-92-2 C₂₄H₂₇FN₂O*0.5C₆H₈O₇ 

Relevant articles and documents

Discovery of a potent analgesic NOP and opioid receptor agonist: Cebranopadol

In a previous communication, our efforts leading from 1 to the identification of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amine 2a as analgesic NOP and opioid receptor agonist were disclosed and their favorable in vitro and in vivo pharmacological properties revealed. We herein report our efforts to further optimize lead 2a, toward trans-6′-fluoro-4′, 9′-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1′(3′H) -pyrano[3,4-b]indol]-4-amine (cebranopadol, 3a), which is currently in clinical development for the treatment of severe chronic nociceptive and neuropathic pain.