2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide

Base Information

• Chemical Name: 2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide
• CAS No.: 97420-40-1
• Molecular Formula: C10H12N4O
• Molecular Weight: 204.231
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID301232453
• Nikkaji Number: J3.367.535F
• ChEMBL ID: CHEMBL1702601
• Mol file: 97420-40-1.mol

Synonyms:2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide;97420-40-1;2-(2-methylbenzimidazol-1-yl)acetohydrazide;2-(2-methyl-1H-1,3-benzodiazol-1-yl)acetohydrazide;(2-Methyl-benzoimidazol-1-yl)-acetic acid hydrazide;Oprea1_532721;Oprea1_658460;MLS000709307;CHEMBL1702601;DTXSID301232453;HMS2588E19;BBL003734;MFCD00227235;STK192178;AKOS000116750;SMR000289974;VS-01409;CS-0219371;EN300-03831;(2-Methyl-1H-benzoimidazole-1-yl)acetohydrazide;(2-Methylbenzoimidazol-1-yl)acetic acid hydrazide;2-(2-methyl-1h-benzimidazol-1-yl) acetohydrazide;2-Methyl-1H-benzimidazole-1-acetic acid hydrazide;(2-Methyl-benzoimidazol-1-yl)-acetic acid, hydrazide;Z56782959

Chemical Property of 2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide

Chemical Property:

• PSA: 72.94000
• LogP: 1.42580
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 204.10111102
• Heavy Atom Count: 15
• Complexity: 246

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=CC=CC=C2N1CC(=O)NN

Technology Process of 2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide

There total 3 articles about 2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 2-(2-methyl-1H-benzo[d]imidazol-1-yl)acetate (97420-36-5) → 2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide (97420-40-1)

Guidance literature:

With hydrazine hydrate; In methanol; at 18 - 20 ℃; for 12h;

DOI:10.1007/BF00534469

Reference yield: 92.0%

methyl 2-(2-methyl-1H-benzimidazol-1-yl)acetate (2033-54-7) → 2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide (97420-40-1)

Guidance literature:

With hydrazine hydrate; In methanol; at 65 ℃; for 16h;

DOI:10.1021/ml400234x

Reference yield:

2-Methyl-1H-benzimidazole (615-15-6) → 2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide (97420-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / polyethylene glycol-4000; K₂CO₃ / acetone / 20 °C

2: 94 percent / 98 percent hydrazine hydrate / methanol / 3 h / Heating

With polyethylene glycol-4000; potassium carbonate; hydrazine hydrate; In methanol; acetone;

upstream raw materials:

ethyl 2-(2-methyl-1H-benzo[d]imidazol-1-yl)acetate

2-Methyl-1H-benzimidazole

methyl 2-(2-methyl-1H-benzimidazol-1-yl)acetate

Downstream raw materials:

C₁₈H₁₉N₅OS

4-phenyl-1-[1-carbonylmethyl-(2-methyl-1H-benzimidazole)]-thiosemicarbazide

C₁₇H₂₃N₅OS

4-(4'-methylphenyl)-1-[1-carbonylmethyl-(2-methyl-1H-benzimidazole)]-thiosemicarbazide