4-Amino-2,8-dimethylquinoline

Base Information

• Chemical Name: 4-Amino-2,8-dimethylquinoline
• CAS No.: 51617-12-0
• Molecular Formula: C₁₁H₁₂N₂
• Molecular Weight: 172.23
• Hs Code.: 2933499090
• European Community (EC) Number: 803-826-7
• DSSTox Substance ID: DTXSID60497033
• Wikidata: Q82346350
• Mol file: 51617-12-0.mol

Synonyms:4-Amino-2,8-dimethylquinoline;51617-12-0;2,8-DIMETHYLQUINOLIN-4-AMINE;SCHEMBL438224;DTXSID60497033;BCA61712;MFCD08669719;AKOS005208993;AB46037;4-Amino-2,8-dimethylquinoline, AldrichCPR;FT-0762410

Chemical Property of 4-Amino-2,8-dimethylquinoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 339.996°C at 760 mmHg
• Flash Point: 186.091°C
• PSA: 38.91000
• Density: 1.136g/cm³
• LogP: 3.01500
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 172.100048391
• Heavy Atom Count: 13
• Complexity: 181

Purity/Quality:

98%Min ^*data from raw suppliers

4-Amino-2,8-dimethylquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C(=CC=C1)C(=CC(=N2)C)N

Technology Process of 4-Amino-2,8-dimethylquinoline

There total 4 articles about 4-Amino-2,8-dimethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2,8-dimethylquinoline (32314-39-9) + phenylhydrazine (100-63-0) → 4-Amino-2,8-dimethylchinolin (51617-12-0)

Guidance literature:

With paraffin oil; at 200 ℃; Erwaermen des Reaktionsprodukts mit Zink und konz. wss. HCl;

DOI:10.1039/jr9380001083

Reference yield:

2,8-dimethyl-quinoline-4-carboxylic acid amide (511241-69-3) → 4-Amino-2,8-dimethylchinolin (51617-12-0)

Guidance literature:

With potassium hydroxide; bromine;

DOI:10.1039/jr9490001803

Reference yield:

7-methyl-1H-indole-2,3-dione (1127-59-9) → 4-Amino-2,8-dimethylchinolin (51617-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous NH₃

2: bromine; aqueous KOH

With potassium hydroxide; ammonium hydroxide; bromine;

DOI:10.1039/jr9490001803

upstream raw materials:

4-chloro-2,8-dimethylquinoline

phenylhydrazine

2,8-dimethyl-quinoline-4-carboxylic acid amide

7-methyl-1H-indole-2,3-dione