2-[2-(4-methoxyphenyl)ethenyl]quinazolin-4(1H)-one

Base Information

• Chemical Name: 2-[2-(4-methoxyphenyl)ethenyl]quinazolin-4(1H)-one
• CAS No.: 30507-21-2
• Molecular Formula: C17H14 N2 O2
• Molecular Weight: 278.31
• Mol file: 30507-21-2.mol

Synonyms:4(1H)-Quinazolinone,2-[2-(4-methoxyphenyl)ethenyl]- (9CI); 4(3H)-Quinazolinone,2-(p-methoxystyryl)- (8CI); 4-Quinazolinol, 2-(p-methoxystyryl)- (7CI); NSC147880

Chemical Property of 2-[2-(4-methoxyphenyl)ethenyl]quinazolin-4(1H)-one

Chemical Property:

• Vapor Pressure: 1.96E-09mmHg at 25°C
• Boiling Point: 481.6°Cat760mmHg
• Flash Point: 245.1°C
• Density: 1.19g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[2-(4-methoxyphenyl)ethenyl]quinazolin-4(1H)-one

There total 9 articles about 2-[2-(4-methoxyphenyl)ethenyl]quinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(2-hydroxy-2-(4-methoxyphenyl)ethyl)quinazolin-4(3H)-one (50324-44-2) → 2-[(E)-2-(4-methoxyphenyl)ethenyl]quinazolin-4(3H)-one (30507-21-2)

Guidance literature:

With trifluoroacetic acid; In methanol; for 3h; Heating;

DOI:10.1002/jhet.5570430436

Reference yield: 75.0%

isatoic anhydride (118-48-9) + 4-methoxy-benzaldehyde (123-11-5) + Triethyl orthoacetate (78-39-7) → 2-[(E)-2-(4-methoxyphenyl)ethenyl]quinazolin-4(3H)-one (30507-21-2)

Guidance literature:

isatoic anhydride; Triethyl orthoacetate; With ammonia; In neat (no solvent); at 120 ℃; for 5h; Green chemistry;

4-methoxy-benzaldehyde; In neat (no solvent); at 120 ℃; for 5h; Temperature; Green chemistry;

DOI:10.1039/c5ra03888j

Reference yield: 57.0%

2-methyl-4-quinazolone (1769-24-0) + 4-methoxy-benzaldehyde (123-11-5) → 2-[(E)-2-(4-methoxyphenyl)ethenyl]quinazolin-4(3H)-one (30507-21-2)

Guidance literature:

With sulfuric acid; at 190 ℃; for 1.5h; under 750.075 - 5250.53 Torr; Microwave irradiation;

DOI:10.1016/j.ejmech.2019.111710

upstream raw materials:

2-methyl-4-quinazolone

4-methoxy-benzaldehyde

2-(2-hydroxy-2-(4-methoxyphenyl)ethyl)quinazolin-4(3H)-one

isatoic anhydride

Downstream raw materials:

4-chloro-2-((E)-2-(4-methoxy-phenyl)-vinyl)-quinazoline

4-chloro-2-(4-methoxy-phenethyl)-quinazoline

2-<2-(4-methoxyphenyl)ethyl>quinazolin-4(3H)-one