Methyl 2-(2-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfaMoyl)-5-(2,2,2-trifluoroacetaMido)phenyl)acetate

Base Information

Chemical Name:Methyl 2-(2-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfaMoyl)-5-(2,2,2-trifluoroacetaMido)phenyl)acetate
CAS No.:1308254-75-2
Molecular Formula:C18H16BF3N2O7S
Molecular Weight:472.206
Hs Code.:

Synonyms:Methyl 2-(2-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfaMoyl)-5-(2,2,2-trifluoroacetaMido)phenyl)acetate

Suppliers and Price of Methyl 2-(2-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfaMoyl)-5-(2,2,2-trifluoroacetaMido)phenyl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of Methyl 2-(2-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfaMoyl)-5-(2,2,2-trifluoroacetaMido)phenyl)acetate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Methyl 2-(2-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfaMoyl)-5-(2,2,2-trifluoroacetaMido)phenyl)acetate

There total 6 articles about Methyl 2-(2-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfaMoyl)-5-(2,2,2-trifluoroacetaMido)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1308256-00-9
methyl 2-(2-(chlorosulfonyl)-5-(2,2,2-trifluoroacetamido)phenyl)acetate

: 117098-94-9
(5-amino-2-hydroxymethylphenyl)boronic acid

: 1308254-75-2
methyl 2-(2-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-5-(2,2,2-trifluoroacetamido)phenyl)acetate

Guidance literature:: With 4-methyl-morpholine; In acetonitrile; at 0 - 20 ℃;

Reference yield:

: 52913-11-8
(3-amino-phenyl)-acetic acid methyl ester

: 1308254-75-2
methyl 2-(2-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-5-(2,2,2-trifluoroacetamido)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 - 20 °C

2: chlorosulfonic acid / 2 h / 0 - 20 °C / Neat (no solvent)

3: 4-methyl-morpholine / acetonitrile / 0 - 20 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; chlorosulfonic acid; In dichloromethane; acetonitrile;

Reference yield:

: 3958-57-4
1-bromomethyl-3-nitrobenzene

: 1308254-75-2
methyl 2-(2-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-5-(2,2,2-trifluoroacetamido)phenyl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-dimethyl-formamide / 5 h / 50 °C

2: hydrogenchloride / methanol / 20 °C

3: hydrogenchloride; iron / water; methanol / 20 °C

4: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 - 20 °C

5: chlorosulfonic acid / 2 h / 0 - 20 °C / Neat (no solvent)

6: 4-methyl-morpholine / acetonitrile / 0 - 20 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; hydrogenchloride; chlorosulfonic acid; iron; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;