6-Bromo-benzo[b]thiophene-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 6-Bromo-benzo[b]thiophene-3-carboxylic acid ethyl ester
• CAS No.: 946427-88-9
• Molecular Formula: C₁₁H₉BrO₂S
• Molecular Weight: 285.161
• Mol file: 946427-88-9.mol

Synonyms:6-Bromo-benzo[b]thiophene-3-carboxylic acid ethyl ester;ethyl 6-bromo-1-benzothiophene-3-carboxylate

Chemical Property of 6-Bromo-benzo[b]thiophene-3-carboxylic acid ethyl ester

Chemical Property:

• Boiling Point: 370.3±22.0 °C(Predicted)
• PSA: 54.54000
• Density: 1.553±0.06 g/cm3(Predicted)
• LogP: 3.84050

Purity/Quality:

97% ^*data from raw suppliers

Ethyl6-bromobenzo[b]thiophene-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Bromo-benzo[b]thiophene-3-carboxylic acid ethyl ester

There total 3 articles about 6-Bromo-benzo[b]thiophene-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

6-bromobenzothiophene (17347-32-9) + ethanol (64-17-5) → 6-bromo-benzo[b]thiophene-3-carboxylic acid ethyl ester (946427-88-9)

Guidance literature:

6-bromobenzothiophene; oxalyl dichloride; With aluminum (III) chloride; In dichloromethane; at -25 - 20 ℃; for 2.5 - 3h;

ethanol; In dichloromethane; at -10 - 70 ℃; for 1h; Product distribution / selectivity;

Reference yield: 51.0%

6-bromobenzothiophene (17347-32-9) + oxalyl dichloride (79-37-8) + ethanol (64-17-5) → 6-bromo-benzo[b]thiophene-3-carboxylic acid ethyl ester (946427-88-9)

Guidance literature:

6-bromobenzothiophene; oxalyl dichloride; With aluminum (III) chloride; In dichloromethane; at -25 - 20 ℃; for 3h;

ethanol; In dichloromethane; at -10 - 70 ℃; for 1h; Product distribution / selectivity;

Reference yield: 44.0%

ethanol (64-17-5) + 6-bromobenzothiophene-3-carboxylic acid (19075-61-7) → 6-bromo-benzo[b]thiophene-3-carboxylic acid ethyl ester (946427-88-9)

Guidance literature:

With sulfuric acid; In water; at 65 ℃; for 72h; Product distribution / selectivity;

upstream raw materials:

6-bromobenzothiophene

ethanol

6-bromobenzothiophene-3-carboxylic acid

oxalyl dichloride