2-(2-cyano-4-Methoxyphenyl)acetic acid

Base Information

• Chemical Name: 2-(2-cyano-4-Methoxyphenyl)acetic acid
• CAS No.: 52786-67-1
• Molecular Formula: C10H9NO3
• Molecular Weight: 191.186
• Hs Code.: 2926907090
• Mol file: 52786-67-1.mol

Synonyms:2-(2-cyano-4-Methoxyphenyl)acetic acid;2-Cyano-4-Methoxyphenylacetic acid

Chemical Property of 2-(2-cyano-4-Methoxyphenyl)acetic acid

Chemical Property:

• PSA: 70.32000
• LogP: 1.19398
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Cyano-4-methoxyphenyl)aceticacid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-cyano-4-Methoxyphenyl)acetic acid

There total 4 articles about 2-(2-cyano-4-Methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(2-bromo-4-methoxy-phenyl)-acetic acid (1261620-25-0) → (2-cyano-4-methoxyphenyl)acetic acid (52786-67-1)

Guidance literature:

(2-bromo-4-methoxy-phenyl)-acetic acid; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 55 ℃;

With water; sodium hydroxide; pH=14;

With hydrogenchloride; In water; ethyl acetate; pH=2 - 3;

Reference yield:

2-(2-bromo-4-(methoxy)phenyl)acetic acid (66916-99-2) → (2-cyano-4-methoxyphenyl)acetic acid (52786-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 18 h / Reflux

2.1: 1-methyl-pyrrolidin-2-one / 0.25 h / 170 °C / Microwave irradiation

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 55 °C

3.2: pH 14

3.3: pH 2 - 3

With lithium hydroxide monohydrate; sulfuric acid; water; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

Reference yield:

methyl 2-(2-bromo-4-methoxyphenyl)acetate (198630-93-2) → (2-cyano-4-methoxyphenyl)acetic acid (52786-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-methyl-pyrrolidin-2-one / 0.25 h / 170 °C / Microwave irradiation

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 55 °C

2.2: pH 14

2.3: pH 2 - 3

With lithium hydroxide monohydrate; water; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

upstream raw materials:

2-(2-bromo-4-(methoxy)phenyl)acetic acid

methyl 2-(2-bromo-4-methoxyphenyl)acetate

(2-bromo-4-methoxy-phenyl)-acetic acid

Downstream raw materials:

5-methoxy-2-(2-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}-2-oxoethyl)benzonitrile

2-({[(2-cyano-4-methoxyphenyl)acetyl](3-phenylpropyl)amino}methyl)-N-(dimethylsulfamoyl)-5-methyl-1,3-thiazole-4-carboxamide

Refernces

• 1、 -. "2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES". . . Retrieved 2011/10/10.