5-methoxy-2-(2-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}-2-oxoethyl)benzonitrile

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Chemical Name:5-methoxy-2-(2-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}-2-oxoethyl)benzonitrile
CAS No.:1334783-14-0
Molecular Formula:C₃₁H₃₃N₅O₂
Molecular Weight:507.635
Hs Code.:

Synonyms:5-methoxy-2-(2-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}-2-oxoethyl)benzonitrile

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Chemical Property of 5-methoxy-2-(2-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}-2-oxoethyl)benzonitrile

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Technology Process of 5-methoxy-2-(2-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}-2-oxoethyl)benzonitrile

There total 5 articles about 5-methoxy-2-(2-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}-2-oxoethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: C₂₁H₂₆N₄

: 52786-67-1
(2-cyano-4-methoxyphenyl)acetic acid

: 1334783-14-0
5-methoxy-2-(2-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}-2-oxoethyl)benzonitrile

Guidance literature:: (2-cyano-4-methoxyphenyl)acetic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 2h;

C₂₁H₂₆N₄; With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ml500414n

Reference yield:

: 66916-99-2
2-(2-bromo-4-(methoxy)phenyl)acetic acid

: 1334783-14-0
5-methoxy-2-(2-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}-2-oxoethyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 18 h / Reflux

2.1: 1-methyl-pyrrolidin-2-one / 0.25 h / 170 °C / Microwave irradiation

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 55 °C

3.2: pH Ca_.2 - 3

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C

4.2: 2 h / 20 °C

With lithium hydroxide monohydrate; sulfuric acid; water; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1021/ml500414n

Reference yield:

: 198630-93-2
methyl 2-(2-bromo-4-methoxyphenyl)acetate

: 1334783-14-0
5-methoxy-2-(2-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}-2-oxoethyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-methyl-pyrrolidin-2-one / 0.25 h / 170 °C / Microwave irradiation

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 55 °C

2.2: pH Ca_.2 - 3

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C

3.2: 2 h / 20 °C

With lithium hydroxide monohydrate; water; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1021/ml500414n