METHYL-2-BROMO-4-METHOXYPHENYLACETATE

Base Information

• Chemical Name: METHYL-2-BROMO-4-METHOXYPHENYLACETATE
• CAS No.: 198630-93-2
• Molecular Formula: C10H11BrO3
• Molecular Weight: 259.1
• Mol file: 198630-93-2.mol

Synonyms:(2-bromo-4-methoxy-phenyl)-acetic acid;METHYL-2-BROMO-4-METHOXYPHENYLACETATE;(2-bromo-4-methoxy-phenyl)-acetic acid methyl ester;

Chemical Property of METHYL-2-BROMO-4-METHOXYPHENYLACETATE

Chemical Property:

• PSA: 35.53000
• LogP: 2.17320

Purity/Quality:

99% ^*data from raw suppliers

METHYL-2-BROMO-4-METHOXYPHENYLACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL-2-BROMO-4-METHOXYPHENYLACETATE

There total 4 articles about METHYL-2-BROMO-4-METHOXYPHENYLACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 2-(2-bromo-4-(methoxy)phenyl)acetic acid (66916-99-2) → methyl 2-(2-bromo-4-methoxyphenyl)acetate (198630-93-2)

Guidance literature:

With sulfuric acid; for 0.5h; Reflux;

DOI:10.1016/j.tet.2013.07.095

Reference yield:

3-bromo-4-methylanisole (36942-56-0) → methyl 2-(2-bromo-4-methoxyphenyl)acetate (198630-93-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / Br₂, (PhCO₂)2 / CCl₄ / 1 h / Heating

2: dimethylsulfoxide / 0.75 h / Ambient temperature

3: aq. KOH / ethanol

4: conc. H₂SO₄ / Heating

With potassium hydroxide; sulfuric acid; bromine; dibenzoyl peroxide; In tetrachloromethane; ethanol; dimethyl sulfoxide;

Reference yield:

2-bromo-1-(bromomethyl)-4-methoxybenzene (54788-18-0) → methyl 2-(2-bromo-4-methoxyphenyl)acetate (198630-93-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylsulfoxide / 0.75 h / Ambient temperature

2: aq. KOH / ethanol

3: conc. H₂SO₄ / Heating

With potassium hydroxide; sulfuric acid; In ethanol; dimethyl sulfoxide;

upstream raw materials:

methanol

2-(2-bromo-4-(methoxy)phenyl)acetic acid

3-bromo-4-methylanisole

2-bromo-1-(bromomethyl)-4-methoxybenzene

Downstream raw materials:

2-(2-bromo-4-methoxyphenyl)ethan-1-ol

2-(4-methoxyphenethyl)-3,3-dimethyl-1-methylenecyclohexane

1-(p-methoxyphenylethyl)-2,6,6-trimethylcyclohex-1-ene

2-<2-(2-Bromo-4-methoxyphenyl)ethyl>-3,3-dimethylcyclohexanone