6-Fluoro-3-iodo-1-methyl-1H-indazole

Base Information

• Chemical Name: 6-Fluoro-3-iodo-1-methyl-1H-indazole
• CAS No.: 1257535-15-1
• Molecular Formula: C₈H₆FIN₂
• Molecular Weight: 276.052
• Hs Code.: 2933998090
• Mol file: 1257535-15-1.mol

Synonyms:6-Fluoro-3-iodo-1-methyl-1H-indazole

Chemical Property of 6-Fluoro-3-iodo-1-methyl-1H-indazole

Chemical Property:

• PSA: 17.82000
• LogP: 2.31700

Purity/Quality:

98%min ^*data from raw suppliers

6-Fluoro-3-iodo-1-methyl-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Fluoro-3-iodo-1-methyl-1H-indazole

There total 3 articles about 6-Fluoro-3-iodo-1-methyl-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-fluoro-3-iodo-1H-indazole (885522-07-6) + methyl iodide (74-88-4) → 6-fluoro-3-iodo-1-methyl-1H-indazole (1257535-15-1)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 1.5h;

Reference yield: 61.0%

→ 6-fluoro-3-iodo-1-methyl-1H-indazole (1257535-15-1) + 6-fluoro-3-iodo-2-methyl-2H-indazole

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃;

Reference yield:

6-fluoro-1H-indazole (348-25-4) → 6-fluoro-3-iodo-1-methyl-1H-indazole (1257535-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 20 °C

2: potassium tert-butylate / 0 - 20 °C

With potassium tert-butylate; iodine; potassium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.02.012

upstream raw materials:

6-fluoro-3-iodo-1H-indazole

methyl iodide

6-fluoro-1H-indazole

Refernces

• 1、 -. "HISTONE DEMETHYLASE INHIBITORS". Paragraph 00162. . Retrieved 2016/04/20.
• 2、 Lynch, Stephen M.,Devicente, Javier,Hermann, Johannes C.,Jaime-Figueroa, Saul,Jin, Sue,Kuglstatter, Andreas,Li, Hongju,Lovey, Allen,Menke, John,Niu, Linghao,Patel, Vaishali,Roy, Douglas,Soth, Michael,Steiner, Sandra,Tivitmahaisoon, Parcharee,Vu, Minh Diem,Yee, Calvin. "Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome". . p. 2793 - 2800. Retrieved 2013/07/05.