tetralin-2-yl propanoate

Base Information

• Chemical Name: tetralin-2-yl propanoate
• CAS No.: 63021-02-3
• Molecular Formula: C13H16O2
• Molecular Weight: 204.2649
• Hs Code.: 2915509000
• Mol file: 63021-02-3.mol

Synonyms:Propionsaeure-(1,2,3,4-tetrahydro-[2]naphthylester);(+-)-2-Propionyloxy-tetralin;(+-)-(1.2.3.4-Tetrahydro-naphthyl-(2))-propionat;propionic acid-(1,2,3,4-tetrahydro-[2]naphthyl ester);2-Naphthalenol,2,3,4-tetrahydro-,propanoate;(+-)-2-Propionyloxy-1.2.3.4-tetrahydro-naphthalin;

Chemical Property of tetralin-2-yl propanoate

Chemical Property:

• Vapor Pressure: 0.00142mmHg at 25°C
• Boiling Point: 296.7°Cat760mmHg
• Flash Point: 125.7°C
• PSA: 26.30000
• Density: 1.07g/cm³
• LogP: 2.49710

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tetralin-2-yl propanoate

There total 5 articles about tetralin-2-yl propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-Phenylbut-1-ene (768-56-9) + propionic acid (802294-64-0,79-09-4) → 1,2,3,4-tetrahydronaphthalen-2-yl propionate (63021-02-3)

Guidance literature:

With palladium diacetate; Selectfluor; In acetonitrile; at 20 ℃;

DOI:10.1021/acs.orglett.5b00376

Reference yield: 77.0%

1,2,3,4-tetrahydronaphthalen-2 ol (530-91-6) + propionyl chloride (79-03-8) → 1,2,3,4-tetrahydronaphthalen-2-yl propionate (63021-02-3)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; Cooling with ice;

DOI:10.1016/j.tetlet.2020.151682

Reference yield:

benzyl bromide (100-39-0) → 1,2,3,4-tetrahydronaphthalen-2-yl propionate (63021-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 4 h / 20 °C

2: palladium diacetate; Selectfluor / acetonitrile / 20 °C

With palladium diacetate; Selectfluor; In tetrahydrofuran; acetonitrile;

DOI:10.1021/acs.orglett.5b00376

upstream raw materials:

4-Phenylbut-1-ene

propionic acid

benzyl bromide

1,2,3,4-tetrahydronaphthalen-2 ol

Refernces

• 1、 Liu, Rui,Lu, Ze-Hai,Hu, Xiao-Hui,Li, Jun-Li,Yang, Xian-Jin. "Monocarboxylation and intramolecular coupling of butenylated arenes via palladium-catalyzed C-H activation process". supporting information. p. 1489 - 1492. Retrieved 2015/03/30.