Methyl 6-(diMethylaMino)-2-naphthoate

Base Information

• Chemical Name: Methyl 6-(diMethylaMino)-2-naphthoate
• CAS No.: 5043-06-1
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.2744
• Hs Code.: 2922499990
• Mol file: 5043-06-1.mol

Synonyms:Methyl 6-(diMethylaMino)-2-naphthoate

Chemical Property of Methyl 6-(diMethylaMino)-2-naphthoate

Chemical Property:

• PSA: 29.54000
• LogP: 2.69240
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

Methyl6-(dimethylamino)-2-naphthoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 6-(diMethylaMino)-2-naphthoate

There total 4 articles about Methyl 6-(diMethylaMino)-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-amino-2-naphthoic acid (116668-47-4) + methyl iodide (74-88-4) → methyl 6-(dimethylamino)-2-naphthoate (5043-06-1)

Guidance literature:

6-amino-2-naphthoic acid; methyl iodide; With sodium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 16h; Inert atmosphere;

With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.organomet.6b00255

Reference yield: 85.0%

methanol (67-56-1) + 6-(N,N-dimethylamino)-2-naphthoic acid (5043-05-0) → methyl 6-(dimethylamino)-2-naphthoate (5043-06-1)

Guidance literature:

With sulfuric acid; for 20h; Reagent/catalyst; Reflux;

DOI:10.1080/00304948.2017.1260396

Reference yield: 60.9%

methyl 6-amino-2-naphthoate (5159-59-1) + methyl iodide (74-88-4) → methyl 6-(dimethylamino)-2-naphthoate (5043-06-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 10h;

DOI:10.1016/j.cclet.2019.04.058

upstream raw materials:

methanol

6-(N,N-dimethylamino)-2-naphthoic acid

6-amino-2-naphthoic acid

methyl iodide

Downstream raw materials:

6-(dimethylamino)naphthalene-2-methanol

Refernces

• 1、 Liu, Nan,Chen, Peng-Zhong,Wang, Jian-Xin,Niu, Li-Ya,Yang, Qing-Zheng. "Difluoroboron β-diketonate dye with intense red/near-infrared fluorescence in solutions and solid states". . p. 1939 - 1941. Retrieved 2019.
• 2、 Ling, Ke-Qing,Sayre, Lawrence M.. "Discovery of a sensitive, selective, and tightly binding fluorogenic substrate of bovine plasma amine oxidase". supporting information; experimental part. p. 339 - 350. Retrieved 2009/04/11.