5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone

Base Information

Chemical Name:5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone
CAS No.:1176-88-1
Molecular Formula:C21H22 O9
Molecular Weight:418.4
Hs Code.:
NSC Number:618935
UNII:07JTS22V9J
DSSTox Substance ID:DTXSID50151834
Nikkaji Number:J374.263F
Wikidata:Q27236309
Metabolomics Workbench ID:26426
ChEMBL ID:CHEMBL422237
Mol file:1176-88-1.mol

Synonyms:2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-chromen-4-one;5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone;5-OH-HxMF

Suppliers and Price of 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 14 raw suppliers

Chemical Property of 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone

Chemical Property:

Vapor Pressure:1.49E-16mmHg at 25°C
Boiling Point:631.7°Cat760mmHg
Flash Point:221.4°C
Density:1.37g/cm³
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:418.12638228
Heavy Atom Count:30
Complexity:636

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C(=C(C(=C3O2)OC)OC)OC)O)OC)OC

Technology Process of 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone

There total 11 articles about 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1178-24-1
3,3',4',5,6,7,8-heptamethoxyflavone

: 1176-88-1
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone

Guidance literature:: With aluminum (III) chloride; In acetonitrile; at 60 ℃; for 3h;
DOI:10.3184/174751914X13966139490181

Reference yield:

: 61451-85-2
3',4',5,7-tetrahydroxy-3,6,8-trimethoxyflavone

: 74-88-4
methyl iodide

: 1176-88-1
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone

Guidance literature:: With potassium carbonate; In acetone; for 1h; Heating;
DOI:10.1016/S0031-9422(00)84904-3

Reference yield:

: 478-01-3
nobiletin

: 1176-88-1
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; sodium carbonate; potassium hydrogensulfate / water; acetone; dichloromethane / 24 h / 5 °C

2: potassium carbonate / acetone / 2 h / 20 °C

3: aluminum (III) chloride / acetonitrile / 3 h / 60 °C

With aluminum (III) chloride; potassium hydrogensulfate; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; In dichloromethane; water; acetone; acetonitrile;
DOI:10.3184/174751914X13966139490181