5-Bromo-1-ethoxy-2,3-difluoro-benzene

Base Information

• Chemical Name: 5-Bromo-1-ethoxy-2,3-difluoro-benzene
• CAS No.: 204654-92-2
• Molecular Formula: C₈H₇BrF₂O
• Molecular Weight: 237.044
• Mol file: 204654-92-2.mol

Synonyms:5-Bromo-1-ethoxy-2,3-difluoro-benzene;B90002

Chemical Property of 5-Bromo-1-ethoxy-2,3-difluoro-benzene

Chemical Property:

• Boiling Point: 213.9±35.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.533±0.06 g/cm3(Predicted)
• LogP: 3.12600

Purity/Quality:

98%min ^*data from raw suppliers

5-bromo-1-ethoxy-2,3-difluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-1-ethoxy-2,3-difluoro-benzene

There total 2 articles about 5-Bromo-1-ethoxy-2,3-difluoro-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl iodide (75-03-6) + 5-bromo-2,3-difluoro-phenol → 3,4-difluoro-5-ethoxybromobenzene (204654-92-2)

Guidance literature:

5-bromo-2,3-difluoro-phenol; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h; Inert atmosphere;

ethyl iodide; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

3,4,5-trifluoro-1-bromobenzene (138526-69-9) → 3,4-difluoro-5-ethoxybromobenzene (204654-92-2)

Guidance literature:

With potassium hydroxide; In ethanol; water;

Reference yield:

3,4-difluoro-5-ethoxybromobenzene (204654-92-2) + 4-ethoxy-3-fluoro-benzaldehyde (452-00-6) → C17H17F3O2

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -75 - -70 °C / Inert atmosphere

1.2: 3 h / -75 - 70 °C / Inert atmosphere

2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 10 h / -75 - 20 °C / Inert atmosphere

With triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; dichloromethane;

upstream raw materials:

3,4,5-trifluoro-1-bromobenzene

ethyl iodide

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