2-(azetidin-3-ylidene)acetonitrile (hydrochloride)

Base Information

• Chemical Name: 2-(azetidin-3-ylidene)acetonitrile (hydrochloride)
• CAS No.: 1314910-43-4
• Molecular Formula: C5H7ClN2
• Molecular Weight: 130.577
• Hs Code.: 2933998090
• Mol file: 1314910-43-4.mol

Synonyms:2-(azetidin-3-ylidene)acetonitrile (hydrochloride);2-(3-Azetidinylidene)acetonitrile hydrochloride (1:1)

Chemical Property of 2-(azetidin-3-ylidene)acetonitrile (hydrochloride)

Chemical Property:

• PSA: 35.82000
• LogP: 1.17038
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-(azetidin-3-ylidene)acetonitrilehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(azetidin-3-ylidene)acetonitrile (hydrochloride)

There total 3 articles about 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester (1153949-11-1) → 2-(azetidin-3-ylidene)acetonitrile hydrochloride (1314910-43-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2.5h; Time; Inert atmosphere; Cooling with ice;

Reference yield:

3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester (1153949-11-1) → 2-(azetidin-3-ylidene)acetonitrile hydrochloride (1314910-43-4) + C5H7ClN2*ClH (1379208-59-9)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 0 - 20 ℃;

Reference yield:

dichloromethane (75-09-2) + 3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester (1153949-11-1) → 2-(azetidin-3-ylidene)acetonitrile hydrochloride (1314910-43-4)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester

dichloromethane

Downstream raw materials:

2-[1-(ethanesulfonyl)azetidin-3-ylidene]acetonitrile

2-(3-chloro-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile

2-(1-{1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl}-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile adipate

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