Methyl 2-(4-chlorophenyl)-2-methylpropanoate

Base Information

• Chemical Name: Methyl 2-(4-chlorophenyl)-2-methylpropanoate
• CAS No.: 57225-86-2
• Molecular Formula: C11H13ClO2
• Molecular Weight: 212.676
• Hs Code.: 2916399090
• Mol file: 57225-86-2.mol

Synonyms:Methyl 2-(4-chlorophenyl)-2-methylpropanoate;Methyl 2-(4-chlorophenyl)-2-methylpropionate

Chemical Property of Methyl 2-(4-chlorophenyl)-2-methylpropanoate

Chemical Property:

• PSA: 26.30000
• LogP: 2.79060

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-(4-chlorophenyl)-2-methylpropanoate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(4-chlorophenyl)-2-methylpropanoate

There total 7 articles about Methyl 2-(4-chlorophenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(4-chloro-phenyl)-acetic acid methyl ester (52449-43-1) + methyl iodide (74-88-4) → methyl 2-(4-chlorophenyl)-2-methylpropanoate (57225-86-2)

Guidance literature:

(4-chloro-phenyl)-acetic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 15.5h; Inert atmosphere;

DOI:10.3390/molecules24061023

Reference yield: 89.0%

bromochlorobenzene (106-39-8) + Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) → methyl 2-(4-chlorophenyl)-2-methylpropanoate (57225-86-2)

Guidance literature:

Methyl isobutyrate; With lithium dicyclohexylamide; In toluene; at 20 ℃; for 0.166667h; Inert atmosphere;

bromochlorobenzene; With di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I); In toluene; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol8002578

Reference yield: 85.0%

1-Chloro-4-iodobenzene (637-87-6) + Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) → methyl 2-(4-chlorophenyl)-2-methylpropanoate (57225-86-2)

Guidance literature:

Methyl isobutyrate; With 2,2,6,6-tetramethylpiperidinyl-lithium; In toluene; at 20 ℃; for 0.25h; Glovebox;

1-Chloro-4-iodobenzene; With di-μ-iodobis(tri-t-butylphosphino)dipalladium(l); In toluene; at 20 ℃; chemoselective reaction; Glovebox;

DOI:10.1055/s-0037-1610087

upstream raw materials:

bromochlorobenzene

Methyl isobutyrate

methanol

1-chloro-4-(1-methylethenyl)-benzene

Downstream raw materials:

2-(4-chlorophenyl)-2-methylpropanehydrazide

4-amino-5-[2-(4-chlorophenyl)propan-2-yl]-4H-[1,2,4]-triazole-3-thiol

3-[2-(4-chlorophenyl)propan-2-yl]-6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

3-[2-(4-chlorophenyl)propan-2-yl]-6-(2,3,4-trifluorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

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