1-(1-benzofuran-6-yl)-N-Methylpropan-2-aMine

Base Information

• Chemical Name: 1-(1-benzofuran-6-yl)-N-Methylpropan-2-aMine
• CAS No.: 1354631-79-0
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.257
• Mol file: 1354631-79-0.mol

Synonyms:1-(1-benzofuran-6-yl)-N-Methylpropan-2-aMine;6-(2-MethylaMinopropane)benzofuran;6-Desoxy-MDMA;6-MAPB;ZDCM-04

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Chemical Property of 1-(1-benzofuran-6-yl)-N-Methylpropan-2-aMine

Chemical Property:

• Boiling Point: 279.8±15.0 °C(Predicted)
• PKA: 10.24±0.10(Predicted)
• Density: 1.043±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-benzofuran-6-yl)-N-Methylpropan-2-aMine

There total 2 articles about 1-(1-benzofuran-6-yl)-N-Methylpropan-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzofuran-6-yl)propan-2-one (286836-34-8) + methylamine (74-89-5) → 1-(benzofuran-6-yl)-N-methylpropan-2-amine (1354631-79-0)

Guidance literature:

1-(benzofuran-6-yl)propan-2-one; methylamine; With acetic acid; In methanol; for 0.25h;

With sodium tris(acetoxy)borohydride; In methanol; at 20 ℃; for 17h;

Reference yield:

6-bromo-benzofuran (128851-73-0) → 1-(benzofuran-6-yl)-N-methylpropan-2-amine (1354631-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tributyltin methoxide; palladium dichloride; tris-(o-tolyl)phosphine / toluene / 16 h / 100 °C / Inert atmosphere

2.1: acetic acid / methanol / 0.25 h

2.2: 17 h / 20 °C

With tributyltin methoxide; acetic acid; tris-(o-tolyl)phosphine; palladium dichloride; In methanol; toluene;

upstream raw materials:

6-bromo-benzofuran

1-(benzofuran-6-yl)propan-2-one

methylamine