Decernotinib

Base Information

Chemical Name:Decernotinib
CAS No.:944842-54-0
Molecular Formula:C₁₈H₁₉F₃N₆O
Molecular Weight:392.384
Hs Code.:
Mol file:944842-54-0.mol

Synonyms:Decernotinib;Decernotinib(VX-509);(R)-2-((2-(1H-Pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide;(2R)-2-Methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-N-(2,2,2-trifluoroethyl)butanamide;VRT 831509;VX 509

Suppliers and Price of Decernotinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Decernotinib
50mg
$ 375.00

DC Chemicals
Decernotinib(VX-509,adelatinib) >98%
100 mg
$ 550.00

DC Chemicals
Decernotinib(VX-509,adelatinib) >98%
1 g
$ 1900.00

DC Chemicals
Decernotinib(VX-509,adelatinib) >98%
250 mg
$ 1000.00

Crysdot
Decernotinib 98+%
50mg
$ 569.00

Crysdot
Decernotinib 98+%
25mg
$ 318.00

ChemScene
Decernotinib 99.45%
2mg
$ 72.00

ChemScene
Decernotinib 99.45%
5mg
$ 108.00

ChemScene
Decernotinib 99.45%
10mg
$ 180.00

ChemScene
Decernotinib 99.45%
50mg
$ 600.00

Total 22 raw suppliers

Chemical Property of Decernotinib

Chemical Property:

PSA：99.08000
LogP:4.19230
Solubility.:insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥2.92 mg/mL in EtOH with ultrasonic

Purity/Quality:

98% ^*data from raw suppliers

Decernotinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Decernotinib is a potent and selective Janus kinase 3 inhibitor for treatment of autoimmune diseases.

Technology Process of Decernotinib

There total 24 articles about Decernotinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.7%

: 1417421-97-6
2-((2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide

: (2S)-2-methyl-2-[[2-(1H-pyrrolo[5,4-b]pyridine-3-yl)pyrimidin-4-yl]amino]-N-(2,2,2-trifluoroethyl)butanamide

: 944842-54-0
decernotinib

Guidance literature:: With SFC chromatography; Resolution of racemate;

Reference yield:

: 753-90-2
trifluoroethylamine

: 1417421-82-9
(R)-2-(2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-2-methylbutanoic acid

: 944842-54-0
decernotinib

Guidance literature:: (R)-2-(2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-2-methylbutanoic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; water; at 30 ℃; for 0.5h; Large scale;

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In dichloromethane; at 20 ℃; for 1h; Large scale;

trifluoroethylamine; In dichloromethane; at 20 - 30 ℃; for 5h; Large scale;

Reference yield:

: 226085-18-3
3-bromo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 944842-54-0
decernotinib

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -90 - -80 °C / Large scale

2.1: dichloromethane / 1.08 h / 20 - 30 °C / Large scale

3.1: potassium phosphate / water; acetonitrile / 0.33 h / 30 °C / Large scale

3.2: 12 h / 65 °C / Inert atmosphere; Large scale

4.1: potassium hydroxide; water / 5 h / 75 °C / Large scale

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane; water / 0.5 h / 30 °C / Large scale

5.2: 1 h / 20 °C / Large scale

5.3: 5 h / 20 - 30 °C / Large scale

With potassium phosphate; n-butyllithium; water; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;