(R)-2-methyl-2-(2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)butanoic acid

Base Information

• Chemical Name: (R)-2-methyl-2-(2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)butanoic acid
• CAS No.: 1417421-80-7
• Molecular Formula: C₂₃H₂₃N₅O₄S
• Molecular Weight: 465.533
• Mol file: 1417421-80-7.mol

Synonyms:(R)-2-methyl-2-(2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)butanoic acid

Chemical Property of (R)-2-methyl-2-(2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-methyl-2-(2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)butanoic acid

There total 5 articles about (R)-2-methyl-2-(2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-methylbenzenesulfonyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine (866545-91-7) + (R)-2-(2-chloropyrimidin-4-ylamino)-2-methylbutanoic acid hydrochloride (1417421-81-8) → (R)-2-methyl-2-(2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)butanoic acid (1417421-80-7)

Guidance literature:

(R)-2-(2-chloropyrimidin-4-ylamino)-2-methylbutanoic acid hydrochloride; With potassium phosphate; In water; acetonitrile; at 30 ℃; for 0.333333h; Large scale;

1-(4-methylbenzenesulfonyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; With palladium diacetate; triphenylphosphine; In water; acetonitrile; at 65 ℃; for 12h; Reagent/catalyst; Inert atmosphere; Large scale;

Reference yield:

3-bromo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (226085-18-3) → (R)-2-methyl-2-(2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)butanoic acid (1417421-80-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -90 - -80 °C / Large scale

2.1: dichloromethane / 1.08 h / 20 - 30 °C / Large scale

3.1: potassium phosphate / water; acetonitrile / 0.33 h / 30 °C / Large scale

3.2: 12 h / 65 °C / Inert atmosphere; Large scale

With potassium phosphate; n-butyllithium; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid (882562-39-2) → (R)-2-methyl-2-(2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)butanoic acid (1417421-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 1.08 h / 20 - 30 °C / Large scale

2.1: potassium phosphate / water; acetonitrile / 0.33 h / 30 °C / Large scale

2.2: 12 h / 65 °C / Inert atmosphere; Large scale

With potassium phosphate; In dichloromethane; water; acetonitrile;

upstream raw materials:

3-bromo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid

1-(4-methylbenzenesulfonyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

(R)-2-(2-chloropyrimidin-4-ylamino)-2-methylbutanoic acid hydrochloride

Downstream raw materials:

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