1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid

Base Information

• Chemical Name: 1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid
• CAS No.: 882562-39-2
• Molecular Formula: C14H13 B N2 O4 S
• Molecular Weight: 316.145
• Hs Code.: 2933990090
• Mol file: 882562-39-2.mol

Synonyms:Boronicacid, [1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]- (9CI);[1-[(4-Methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]boronic acid

Chemical Property of 1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid

Chemical Property:

• Vapor Pressure: 4.69E-15mmHg at 25°C
• Refractive Index: 1.647
• Boiling Point: 596.1°C at 760 mmHg
• PKA: 6.82±0.30(Predicted)
• Flash Point: 314.3°C
• PSA: 100.80000
• Density: 1.39±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: 1.34230
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

(1-Tosyl-1H-pyrrolo[2,3-β]pyridin-3-yl)boronicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid

There total 6 articles about 1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.4%

Triisopropyl borate (5419-55-6) + 3-bromo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (226085-18-3) → 1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid (882562-39-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -90 - -80 ℃; for 0.5h; Large scale;

Reference yield: 69.4%

3-bromo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (226085-18-3) → 1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid (882562-39-2)

Guidance literature:

With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; at -90 - -80 ℃; Large scale;

Reference yield: 22.0%

3-iodo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine (664982-01-8) → 1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid (882562-39-2)

Guidance literature:

3-iodo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

With Triisopropyl borate; In tetrahydrofuran; at -78 ℃; for 1h;

upstream raw materials:

3-iodo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

Triisopropyl borate

3-bromo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

7-Azaindole

Downstream raw materials:

(R)-2-methyl-2-(2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)butanoic acid

decernotinib

methyl 2-methyl-2-((2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)butanoate

C₂₁⁽¹³⁾C₄H₂₅F₃N₄⁽¹⁵⁾N₂O₃S

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