2,3-DI-(2-Thienyl)quinoxaline

Base Information

• Chemical Name: 2,3-DI-(2-Thienyl)quinoxaline
• CAS No.: 81321-98-4
• Molecular Formula: C₁₆H₁₀N₂S₂
• Molecular Weight: 294.401
• DSSTox Substance ID: DTXSID30402316
• Nikkaji Number: J848.564J
• Wikidata: Q82205707
• ChEMBL ID: CHEMBL4282833
• Mol file: 81321-98-4.mol

Synonyms:2,3-Di(2-thienyl)quinoxaline;CHEMBL4282833;2,3-DI-(2-THIENYL)QUINOXALINE;81321-98-4;dithienylquinoxaline;2,3-Dithien-2-ylquinoxaline;SCHEMBL16027135;DTXSID30402316;2,3-Di(thiophen-2-yl)quinoxaline;BDBM50468954;AKOS024405212;FT-0609507

Chemical Property of 2,3-DI-(2-Thienyl)quinoxaline

Chemical Property:

• Vapor Pressure: 1.48E-06mmHg at 25°C
• Boiling Point: 410°C at 760 mmHg
• Flash Point: 186.6°C
• PSA: 82.26000
• Density: 1.341g/cm³
• LogP: 5.08680
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 294.02854067
• Heavy Atom Count: 20
• Complexity: 306

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)N=C(C(=N2)C3=CC=CS3)C4=CC=CS4

Technology Process of 2,3-DI-(2-Thienyl)quinoxaline

There total 10 articles about 2,3-DI-(2-Thienyl)quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

thiophene (188290-36-0,8014-23-1,25233-34-5) + 2,3-diethynylquinoxaline (91-19-0) → 2-(thiophen-2-yl)quinoxaline (40353-41-1) + 2,3-bis(thiophen-2-yl)quinoxaline (81321-98-4)

Guidance literature:

thiophene; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -78 - -10 ℃; for 1h; Inert atmosphere;

2,3-diethynylquinoxaline; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 11.5h; Inert atmosphere;

With iodine; In tetrahydrofuran; hexane; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.joc.0c02252

Reference yield: 93.0%

2,2'-thenil (7333-07-5) + 1,2-diamino-benzene (95-54-5) → 2,3-bis(thiophen-2-yl)quinoxaline (81321-98-4)

Guidance literature:

In ethanol; for 3h; Reflux;

DOI:10.4067/S0717-97072014000200014

Reference yield: 90.0%

2,3-diethynylquinoxaline (91-19-0) + thiophen-2-yl magnesium bromide (5713-61-1) → 2,3-bis(thiophen-2-yl)quinoxaline (81321-98-4)

Guidance literature:

2,3-diethynylquinoxaline; thiophen-2-yl magnesium bromide; With N,N,N,N,-tetramethylethylenediamine; In toluene; at 50 ℃; for 10h; Inert atmosphere;

With water; ammonium chloride; In toluene; for 12h;

DOI:10.1021/jo400152f

upstream raw materials:

1,2,3,4-Tetrahydro-2,3-di(2-thienyl)chinoxalin

thiophene-2-carbaldehyde

1,2-diamino-benzene

o-phenylenediamine dihydrochloride