2-bromo-1,4-dimethoxy-3-nitrobenzene

Base Information

• Chemical Name: 2-bromo-1,4-dimethoxy-3-nitrobenzene
• CAS No.: 107135-53-5
• Molecular Formula: C₈H₈BrNO₄
• Molecular Weight: 262.06
• Mol file: 107135-53-5.mol

Synonyms:2-bromo-1,4-dimethoxy-3-nitrobenzene

Chemical Property of 2-bromo-1,4-dimethoxy-3-nitrobenzene

Chemical Property:

• Melting Point: 146-147 °C(Solv: ethanol (64-17-5))
• Boiling Point: 324.0±37.0 °C(Predicted)
• Density: 1.583±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-1,4-dimethoxy-3-nitrobenzene

There total 2 articles about 2-bromo-1,4-dimethoxy-3-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-nitrohydroquinone dimethylether (26002-57-3) → 2-bromo-1,4-dimethoxy-3-nitrobenzene (107135-53-5)

Guidance literature:

With sulfuric acid; hydrogen bromide; copper(I) bromide; sodium nitrite; Yield given. Multistep reaction; 1.) methanol, water, 0 deg C, 30 min, 2.) methanol, water, reflux, 1 h;

DOI:10.1021/jo00383a032

Reference yield:

1,4-dimethoxy-2-nitrobenzene (89-39-4) → 2-bromo-1,4-dimethoxy-3-nitrobenzene (107135-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) HNO₃; 2.) sodium dithionite / 2.) EtOH, heating, 2 h

2: 1.) NaNO₂, conc. H₂SO₄; 2.) CuBr, HBr / 1.) CH₃COOH, 20-25 deg C, 30 min; 2.) r.t.

With sodium dithionite; sulfuric acid; hydrogen bromide; nitric acid; copper(I) bromide; sodium nitrite;

Reference yield: 100.0%

2-bromo-1,4-dimethoxy-3-nitrobenzene (107135-53-5) → 2-bromo-3,6-dimethoxyaniline (107135-54-6)

Guidance literature:

With iron(III) chloride; pyrographite; hydrazine hydrate; In methanol; for 12h; Heating;

DOI:10.1021/jo00383a032

upstream raw materials:

2-amino-3-nitrohydroquinone dimethylether

1,4-dimethoxy-2-nitrobenzene

Downstream raw materials:

2-bromo-3,6-dimethoxyaniline

2-bromo-1,4-dimethoxy-3-iodobenzene

2-bromo-1,4-dimethoxy-3-(phenylethynyl)benzene

1-<3,6-dimethoxy-2-(phenylethynyl)benzoyl>-2,3-dihydro-7-methoxy-1H-indene