2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester

Base Information

• Chemical Name: 2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester
• CAS No.: 37772-85-3
• Molecular Formula: C6H7NO4
• Molecular Weight: 157.12408
• Mol file: 37772-85-3.mol

Synonyms:2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester

Chemical Property of 2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester

Chemical Property:

• Melting Point: >270 °C
• Boiling Point: 389.4±42.0 °C(Predicted)
• PKA: 4.50±1.00(Predicted)
• PSA: 75.63000
• Density: 1.494±0.06 g/cm3(Predicted)
• LogP: -0.56990

Purity/Quality:

99% ^*data from raw suppliers

4-Hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester

There total 7 articles about 2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methanol (67-56-1) + ethyl 3-((2-ethoxy-2-oxoethyl)amino)-3-oxopropanoate (51925-56-5) → methyl 4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate (37772-85-3)

Guidance literature:

methanol; With sodium;

ethyl 3-((2-ethoxy-2-oxoethyl)amino)-3-oxopropanoate; In toluene; for 4h; Reflux;

DOI:10.1002/jhet.2004

Reference yield: 66.0%

methyl hippurylmalonate (83544-51-8) → methyl 4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate (37772-85-3)

Guidance literature:

With sodium ethanolate; In ethanol; benzene; 1.) reflux, 5 h, 2.) stand overnight.;

Reference yield: 59.0%

2-(2-Acetylamino-acetyl)-malonic acid dimethyl ester (105688-25-3) → methyl 4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate (37772-85-3)

Guidance literature:

With sodium methylate; In methanol; benzene; 1.) reflux, 2 h, 2.) room temperature, overnight;;

upstream raw materials:

methyl hippurylmalonate

N-Acetyl-α-carbomethoxytetramic acid

2-(2-Acetylamino-acetyl)-malonic acid dimethyl ester

C₇H₁₁NO₅

Downstream raw materials:

C₁₇H₂₀N₂O₃

pyrrolidine-2,4-dione