3-Difluoromethyl-benzaldehyde

Base Information

• Chemical Name: 3-Difluoromethyl-benzaldehyde
• CAS No.: 945004-44-4
• Molecular Formula: C8H6F2O
• Molecular Weight: 156.132
• Hs Code.: 2913000090
• Mol file: 945004-44-4.mol

Synonyms:3-Difluoromethyl-benzaldehyde;3-(Difluoromethyl)benzaldehyde 98+%;alpha,alpha-Difluoro-m-tolualdehyde, 3-Formylbenzal fluoride

Chemical Property of 3-Difluoromethyl-benzaldehyde

Chemical Property:

• Refractive Index: n20/D1.503
• Flash Point: 102℃
• PSA: 17.07000
• Density: 1.257 g/mL at 25 °C
• LogP: 2.43670

Purity/Quality:

97% ^*data from raw suppliers

3-(Difluoromethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Difluoromethyl-benzaldehyde

There total 5 articles about 3-Difluoromethyl-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

iododifluoromethane (1493-03-4) + 3-Formylphenylboronic acid (87199-16-4) → 3-(difluoromethyl)benzaldehyde (945004-44-4)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; water; toluene; at 60 ℃; for 24h;

DOI:10.1021/acscatal.8b03892

Reference yield: 74.0%

1-bromo-3-difluoromethyl-benzene (29848-59-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(difluoromethyl)benzaldehyde (945004-44-4)

Guidance literature:

1-bromo-3-difluoromethyl-benzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield: 55.0%

Ethyl bromodifluoroacetate (667-27-6) + 3-Formylphenylboronic acid (87199-16-4) → 3-(difluoromethyl)benzaldehyde (945004-44-4)

Guidance literature:

With styrene; bis-triphenylphosphine-palladium(II) chloride; iron(III)-acetylacetonate; potassium carbonate; hydroquinone; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; for 24h; Schlenk technique; Glovebox;

DOI:10.1021/acs.orglett.5b03206

upstream raw materials:

1-bromo-3-difluoromethyl-benzene

N,N-dimethyl-formamide

Ethyl bromodifluoroacetate

3-Formylphenylboronic acid

Downstream raw materials:

N-(3-difluoromethyl-benzylidene)-N-(8-morpholin-4-yl-2-pyridin-4-yl-imidazo[1,2-b]pyridazin-6-yl)-hydrazine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 945004-44-4 3-Difluoromethyl-benzaldehyde

Send

Send

Metric Ton KG G Pound L ML

Send

Send