2-(4-Chlorophenyl)-6-methylpyrimidine-4(3H)-one

Base Information

Chemical Name:2-(4-Chlorophenyl)-6-methylpyrimidine-4(3H)-one
CAS No.:16858-20-1
Molecular Formula:C11H9ClN2O
Molecular Weight:220.658
Hs Code.:2933599090
Mol file:16858-20-1.mol

Synonyms:2-(4-Chlorophenyl)-6-methylpyrimidine-4(3H)-one;2-(p-Chlorophenyl)-6-methyl-4(3H)-pyrimidone

Suppliers and Price of 2-(4-Chlorophenyl)-6-methylpyrimidine-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-(4-Chlorophenyl)-6-methylpyrimidine-4(3H)-one

Chemical Property:

PSA：45.75000
LogP:2.39870

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-(4-Chlorophenyl)-6-methyl-4(3H)-pyrimidinone synthesis of 4-Pyrimidinols.

Technology Process of 2-(4-Chlorophenyl)-6-methylpyrimidine-4(3H)-one

There total 4 articles about 2-(4-Chlorophenyl)-6-methylpyrimidine-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 623-03-0
4-Cyanochlorobenzene

: 105-45-3
acetoacetic acid methyl ester

: 16858-20-1
2-(4-chlorophenyl)-6-methylpyrimidin-4-one

Guidance literature:: 4-Cyanochlorobenzene; With sodium methylate; In methanol; at 20 ℃;

acetoacetic acid methyl ester; With sodium methylate; In methanol; at 20 - 60 ℃;
DOI:10.1016/j.bmc.2012.02.006

Reference yield: 56.0%

: 14401-51-5
4-chlorobenzamidine hydrochloride

: 105-45-3
acetoacetic acid methyl ester

: 16858-20-1
2-(4-chlorophenyl)-6-methylpyrimidin-4-one

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 120h;
DOI:10.1016/j.bmc.2012.06.049

Reference yield:

: 623-03-0
4-Cyanochlorobenzene

: 16858-20-1
2-(4-chlorophenyl)-6-methylpyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / chloroform; ethanol / -78 - 20 °C

1.2: 72 h / 20 °C

2.1: sodium methylate / methanol / 120 h / 20 °C

With hydrogenchloride; sodium methylate; In methanol; ethanol; chloroform;
DOI:10.1016/j.bmc.2012.06.049