3-Nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyriMidine

Base Information

• Chemical Name: 3-Nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyriMidine
• CAS No.: 148777-84-8
• Molecular Formula: C6H8N4O2
• Molecular Weight: 168.15332
• Mol file: 148777-84-8.mol

Synonyms:3-Nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyriMidine;3-nitro-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine

Chemical Property of 3-Nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyriMidine

Chemical Property:

• Boiling Point: 383.7±30.0 °C(Predicted)
• PKA: 0.19±0.20(Predicted)
• PSA: 75.67000
• Density: 1.72±0.1 g/cm3(Predicted)
• LogP: 1.26810

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyriMidine

There total 3 articles about 3-Nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (126352-69-0) → 3-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (148777-84-8)

Guidance literature:

With sulfuric acid; potassium nitrate; at 0 - 20 ℃; for 22h;

Reference yield:

4-formyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (126352-82-7) → 3-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (148777-84-8)

Guidance literature:

With sulfuric acid; potassium nitrate; at 0 - 20 ℃; for 17h;

Reference yield:

4-nitro-1H-pyrazol-3-amine (16115-82-5) + 1,3-dibromo-propane (109-64-8) → 3-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (148777-84-8)

Guidance literature:

In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

4-formyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

4-nitro-1H-pyrazol-3-amine

1,3-dibromo-propane

Refernces

• 1、 -. "CEPHEM COMPOUNDS". Page 51. . Retrieved 2010/02/06.