4-Oxo-Valsartan Benzyl Ester

Base Information

• Chemical Name: 4-Oxo-Valsartan Benzyl Ester
• CAS No.: 188240-32-6
• Molecular Formula: C31H33N5O4
• Molecular Weight: 539.62
• Mol file: 188240-32-6.mol

Synonyms:4-Oxo-Valsartan Benzyl Ester;N-(1,4-Dioxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine Phenylmethyl Ester

Chemical Property of 4-Oxo-Valsartan Benzyl Ester

Chemical Property:

• Boiling Point: 754.3±70.0 °C(Predicted)
• PKA: 4.15±0.10(Predicted)
• Density: 1.220±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility.: Dimethylformamide, Dimethyl Sulfoxide, Methanol

Purity/Quality:

97% ^*data from raw suppliers

4-Oxo Valsartan Benzyl Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate for the synthesis of Valsartan metabolite Intermediate for the synthesis of Valsartan metabolite.

Technology Process of 4-Oxo-Valsartan Benzyl Ester

There total 3 articles about 4-Oxo-Valsartan Benzyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(S)-N-(4-Oxo-valeryl)-N-[(2'-cyano-biphenyl-4-yl)methyl]valine benzyl ester (188240-31-5) → (S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine benzyl ester (188240-32-6)

Guidance literature:

With azido tributyltin (IV); In xylene; Heating;

DOI:10.1080/004982597240767

Reference yield:

4-oxo-pentanoyl chloride (1490-24-0) → (S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine benzyl ester (188240-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / diisopropylethylamine / CH₂Cl₂

2: 41 percent / tri-n-butyl tin azide / xylene / Heating

With N-ethyl-N,N-diisopropylamine; azido tributyltin (IV); In dichloromethane; xylene; 1: Acylation / 2: Cyclization;

DOI:10.1080/004982597240767

Reference yield:

(S)-N-[(2'-Cyano-biphenyl-4-yl)methyl]valine benzyl ester (137864-23-4) → (S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine benzyl ester (188240-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / diisopropylethylamine / CH₂Cl₂

2: 41 percent / tri-n-butyl tin azide / xylene / Heating

With N-ethyl-N,N-diisopropylamine; azido tributyltin (IV); In dichloromethane; xylene; 1: Acylation / 2: Cyclization;

DOI:10.1080/004982597240767

upstream raw materials:

(S)-N-(4-Oxo-valeryl)-N-[(2'-cyano-biphenyl-4-yl)methyl]valine benzyl ester

4-oxo-pentanoyl chloride

(S)-N-[(2'-Cyano-biphenyl-4-yl)methyl]valine benzyl ester

Downstream raw materials:

(S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine

4-Hydroxyvalsartan

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