4,6-DiMethylpyridin-3-carboxylic acid Methyl ester

Base Information

• Chemical Name: 4,6-DiMethylpyridin-3-carboxylic acid Methyl ester
• CAS No.: 69971-44-4
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2933399090
• Mol file: 69971-44-4.mol

Synonyms:4,6-DiMethylpyridin-3-carboxylic acid Methyl ester;4,6-Dimethyl-3-pyridinecarboxylic acid methyl ester;4,6-Dimethylnicotinic acid methyl ester;Methyl 4,6-dimethyl-3-pyridinecarboxylate;Methyl 4,6-dimethylnicotinate

Chemical Property of 4,6-DiMethylpyridin-3-carboxylic acid Methyl ester

Chemical Property:

• Boiling Point: 228℃
• PKA: 4.57±0.18(Predicted)
• Flash Point: 92℃
• PSA: 39.19000
• Density: 1.078
• LogP: 1.48500
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl4,6-dimethylnicotinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-DiMethylpyridin-3-carboxylic acid Methyl ester

There total 4 articles about 4,6-DiMethylpyridin-3-carboxylic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methanol (67-56-1) + Methyl 6-methylnicotinate (5470-70-2) → Methyl 4,6-Dimethylnicotinate (69971-44-4)

Guidance literature:

With Ethyl 2-mercaptopropionate; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; toluene-4-sulfonic acid; In dimethyl sulfoxide; at 23 ℃; UV-irradiation;

DOI:10.1038/nature14885

Reference yield: 5.0%

1,3-DIOXOLANE (646-06-0) + methyl 3-pyridinecarboxylate (93-60-7) → Methyl 6-methylnicotinate (5470-70-2) + Methyl 4,6-Dimethylnicotinate (69971-44-4)

Guidance literature:

With sulfuric acid; for 7h; Irradiation;

DOI:10.1021/jo00221a040

Reference yield:

methanol (67-56-1) + 3-cyano-4,6-dimethylpyridine (6623-21-8) → Methyl 4,6-Dimethylnicotinate (69971-44-4)

Guidance literature:

With sulfuric acid; water; Yield given. Multistep reaction; 1.) reflux, 18h, 2.) 50 deg C, 2h, 3.) 65 deg C, 6.5h;

DOI:10.1021/jo00328a010

upstream raw materials:

1,3-DIOXOLANE

methyl 3-pyridinecarboxylate

methanol

3-cyano-4,6-dimethylpyridine

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