3-(2-AMINO-5-BROMO-PYRIDIN-3-YL)-ACRYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-(2-AMINO-5-BROMO-PYRIDIN-3-YL)-ACRYLIC ACID METHYL ESTER
• CAS No.: 912760-74-8
• Molecular Formula: C₉H₉BrN₂O₂
• Molecular Weight: 257.087
• Mol file: 912760-74-8.mol

Synonyms:3-(2-AMINO-5-BROMO-PYRIDIN-3-YL)-ACRYLIC ACID METHYL ESTER;Methyl 3-(2-amino-5-bromopyridin-3-yl)acrylate

Chemical Property of 3-(2-AMINO-5-BROMO-PYRIDIN-3-YL)-ACRYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 3.89E-05mmHg at 25°C
• Boiling Point: 352.2°C at 760 mmHg
• Flash Point: 166.8°C
• PSA: 65.21000
• Density: 1.586g/cm³
• LogP: 2.19370

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-Amino-5-bromo-pyridin-3-yl)-acrylic acid methyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-AMINO-5-BROMO-PYRIDIN-3-YL)-ACRYLIC ACID METHYL ESTER

There total 3 articles about 3-(2-AMINO-5-BROMO-PYRIDIN-3-YL)-ACRYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C14H17BrN2O3 (1439929-76-6) → C9H9BrN2O2 (912760-74-8)

Guidance literature:

With hydrogenchloride; In methanol; water; at 60 ℃; for 3h;

DOI:10.1021/ol401540k

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) → C9H9BrN2O2 (912760-74-8)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 0 - 20 °C

2: [Cp*RhCl₂]2; silver hexafluoroantimonate; copper diacetate / 1,2-dichloro-ethane / 24 h / 120 °C / Schlenk technique; Inert atmosphere

3: hydrogenchloride / methanol; water / 3 h / 60 °C

With hydrogenchloride; dmap; silver hexafluoroantimonate; [Cp*RhCl₂]2; copper diacetate; triethylamine; In methanol; dichloromethane; water; 1,2-dichloro-ethane;

DOI:10.1021/ol401540k

Reference yield:

N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide (182344-63-4) → C9H9BrN2O2 (912760-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: [Cp*RhCl₂]2; silver hexafluoroantimonate; copper diacetate / 1,2-dichloro-ethane / 24 h / 120 °C / Schlenk technique; Inert atmosphere

2: hydrogenchloride / methanol; water / 3 h / 60 °C

With hydrogenchloride; silver hexafluoroantimonate; [Cp*RhCl₂]2; copper diacetate; In methanol; water; 1,2-dichloro-ethane;

DOI:10.1021/ol401540k

upstream raw materials:

5-bromo-2-pyridylamine

N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide

C₁₄H₁₇BrN₂O₃

Downstream raw materials:

6-bromo-3,4-dihydro-1,8-naphthyridine-2(1H)-one

Refernces