N-(5-Bromopyridin-2-YL)pivalamide

Base Information

• Chemical Name: N-(5-Bromopyridin-2-YL)pivalamide
• CAS No.: 182344-63-4
• Molecular Formula: C10H13BrN2O
• Molecular Weight: 257.13
• DSSTox Substance ID: DTXSID70572986
• Nikkaji Number: J2.166.640H
• Wikidata: Q82461538
• Mol file: 182344-63-4.mol

Synonyms:182344-63-4;N-(5-BROMOPYRIDIN-2-YL)PIVALAMIDE;N-(5-bromopyridin-2-yl)-2,2-dimethylpropanamide;Propanamide, N-(5-bromo-2-pyridinyl)-2,2-dimethyl-;N-(5-Bromo-pyridin-2-yl)-2,2-dimethyl-propionamide;N-(5-bromopyridin-2-yl)-2,2-dimethylpropionamide;SCHEMBL2033431;DTXSID70572986;LHJMFFKVXROWOC-UHFFFAOYSA-N;MFCD08110803;AKOS000475220;AKOS032949921;5-bromo-2-(t-butylcarbonylamino)pyridine;AM805456;AS-68451;CS-0039171;EN300-139526;N-(5-Bromo-pyridin-2-yl)-2,2-dimethylpropionamide;N-(5-bromopyridin-2-yl)-2,2-dimethyl-propionamide

Chemical Property of N-(5-Bromopyridin-2-YL)pivalamide

Chemical Property:

• PSA: 45.48000
• LogP: 3.47820
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 256.02113
• Heavy Atom Count: 14
• Complexity: 213

Purity/Quality:

97% ^*data from raw suppliers

N-(5-Bromopyridin-2-yl)pivalamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C(=O)NC1=NC=C(C=C1)Br

Technology Process of N-(5-Bromopyridin-2-YL)pivalamide

There total 6 articles about N-(5-Bromopyridin-2-YL)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-bromo-2-pyridylamine (1072-97-5) + pivaloyl chloride (3282-30-2) → N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide (182344-63-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1039/c5ob00430f

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) + pivaloyl chloride (3282-30-2) → N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide (182344-63-4)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

N-(5-Bromo-1-oxy-pyridin-2-yl)-2,2-dimethyl-propionamide → N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide (182344-63-4)

Guidance literature:

With tetrahydroxydiboron; for 0.166667h;

DOI:10.1055/s-0033-1340010

upstream raw materials:

5-bromo-2-pyridylamine

2,2-dimethylpropanoic anhydride

pivaloyl chloride

2-amino-5-bromopyridine N-oxide

Downstream raw materials:

N-(5-Vinyl-pyridin-2-yl)-2.2-dimethylpropionamide

C₁₄H₁₇BrN₂O₃

C₁₀H₁₁BrN₂O₂

C₉H₉BrN₂O₂