TERT-BUTYL 4-((METHOXYCARBONYL)METHYL)BENZYLCARBAMATE

Base Information

• Chemical Name: TERT-BUTYL 4-((METHOXYCARBONYL)METHYL)BENZYLCARBAMATE
• CAS No.: 191871-32-6
• Molecular Formula: C15H21NO4
• Molecular Weight: 279.33
• Hs Code.: 2922498590
• Mol file: 191871-32-6.mol

Synonyms:TERT-BUTYL 4-((METHOXYCARBONYL)METHYL)BENZYLCARBAMATE;Benzeneacetic acid, 4-[[[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-, Methyl ester

Chemical Property of TERT-BUTYL 4-((METHOXYCARBONYL)METHYL)BENZYLCARBAMATE

Chemical Property:

• PSA: 68.12000
• LogP: 2.63120

Purity/Quality:

Methyl2-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-((METHOXYCARBONYL)METHYL)BENZYLCARBAMATE

There total 6 articles about TERT-BUTYL 4-((METHOXYCARBONYL)METHYL)BENZYLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

→ [4-(tert-butoxycarbonylamino-methyl)-phenyl]-acetic acid methyl ester (191871-32-6)

Guidance literature:

Reference yield:

ester monomethylique de l'acide p-phenylene diacetique (17833-56-6) + diphenylphosphoranyl azide (4129-17-3) → [4-(tert-butoxycarbonylamino-methyl)-phenyl]-acetic acid methyl ester (191871-32-6)

Guidance literature:

With pyridine; triethylamine; In N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

methyl 4-cyanobenzeneacetate (52798-01-3) → [4-(tert-butoxycarbonylamino-methyl)-phenyl]-acetic acid methyl ester (191871-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr

2: Et₃N / tetrahydrofuran / 25 °C

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2005.03.020

upstream raw materials:

di-tert-butyl dicarbonate

2-(4-(aminomethyl)phenyl)acetic acid methyl ester

methyl 4-cyanobenzeneacetate

(4-bromo-phenyl)-acetic acid methyl ester

Downstream raw materials:

(4-aminomethylphenyl)-acetic acid methyl ester hydrochloride

[4-({methyl-[1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl]-carbamoyl}-methyl)-benzyl]-carbamic acid tert-butyl ester

2-(4-aminomethyl-phenyl)-N-methyl-N-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-acetamide

2-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)acetic acid