1H-IMidazole-1-ethanol, 2-(4-broMo-2-fluorophenyl)-4-[3-Methyl-1-(1-Methylethyl)-1H-1,2,4-triazol-5-yl]-

Base Information

• Chemical Name: 1H-IMidazole-1-ethanol, 2-(4-broMo-2-fluorophenyl)-4-[3-Methyl-1-(1-Methylethyl)-1H-1,2,4-triazol-5-yl]-
• CAS No.: 1282516-77-1
• Molecular Formula: C17H19BrFN5O
• Molecular Weight: 408.273
• Mol file: 1282516-77-1.mol

Synonyms:1H-IMidazole-1-ethanol, 2-(4-broMo-2-fluorophenyl)-4-[3-Methyl-1-(1-Methylethyl)-1H-1,2,4-triazol-5-yl]-;2-(2-(4-bromo-2-fluorophenyl)-4-(1-isopropyl-3-methyl-1H-1,2,4-triazol- 5-yl)-1H-imidazol-1-yl)ethanol

Chemical Property of 1H-IMidazole-1-ethanol, 2-(4-broMo-2-fluorophenyl)-4-[3-Methyl-1-(1-Methylethyl)-1H-1,2,4-triazol-5-yl]-

Chemical Property:

• PSA: 68.76000
• LogP: 3.59180

Purity/Quality:

97% ^*data from raw suppliers

1H-Imidazole-1-ethanol,2-(4-bromo-2-fluorophenyl)-4-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-IMidazole-1-ethanol, 2-(4-broMo-2-fluorophenyl)-4-[3-Methyl-1-(1-Methylethyl)-1H-1,2,4-triazol-5-yl]-

There total 15 articles about 1H-IMidazole-1-ethanol, 2-(4-broMo-2-fluorophenyl)-4-[3-Methyl-1-(1-Methylethyl)-1H-1,2,4-triazol-5-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

[1,3]-dioxolan-2-one (96-49-1) + 5-(2-(4-bromo-2-fluorophenyl)-1H-imidazol-4-yl)-1-isopropyl-3-methyl-1H-1,2,4-triazole (1282516-76-0) → 2-(2-(4-bromo-2-fluorophenyl)-4-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-1H-imidazol-1-yl)ethanol (1282516-77-1)

Guidance literature:

In toluene; for 5h; Reflux;

Reference yield:

acetic acid isopropylidenehydrazide (3742-63-0) → 2-(2-(4-bromo-2-fluorophenyl)-4-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-1H-imidazol-1-yl)ethanol (1282516-77-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogen / platinum(IV) oxide / industrial methylated spirits / 48 h / 20 °C

2.1: trimethoxonium tetrafluoroborate / dichloromethane / 2 h / 20 °C

2.2: 15 h / 20 °C / Reflux

3.1: 1,1-dibromomethane; methyllithium / formaldehyde diethyl acetal / 0.25 h / -78 °C

3.2: -78 - 20 °C

4.1: potassium hydrogencarbonate / water; tetrahydrofuran / 18 h / Reflux

5.1: toluene / 5 h / Reflux

With methyllithium; hydrogen; trimethoxonium tetrafluoroborate; potassium hydrogencarbonate; 1,1-dibromomethane; platinum(IV) oxide; In tetrahydrofuran; industrial methylated spirits; formaldehyde diethyl acetal; dichloromethane; water; toluene;

Reference yield:

N'-isopropylacetohydrazonamide → 2-(2-(4-bromo-2-fluorophenyl)-4-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-1H-imidazol-1-yl)ethanol (1282516-77-1)

Guidance literature:

Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

2: Heating

3: 1-methyl-1H-imidazole / 7 h / 50 - 80 °C

With 1-methyl-1H-imidazole; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide;

upstream raw materials:

[1,3]-dioxolan-2-one

5-(2-(4-bromo-2-fluorophenyl)-1H-imidazol-4-yl)-1-isopropyl-3-methyl-1H-1,2,4-triazole

2-bromo-1-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-ethanone

acetic acid isopropylidenehydrazide

Downstream raw materials:

ethyl 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanoate

2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid

taselisib

9-bromo-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f ]imidazo[1,2-d][1,4]oxazepine

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