1H-1,2,4-Triazole, 5-[2-(4-broMo-2-fluorophenyl)-1H-iMidazol-5-yl]-3-Methyl-1-(1-Methylethyl)-

Base Information

Chemical Name:1H-1,2,4-Triazole, 5-[2-(4-broMo-2-fluorophenyl)-1H-iMidazol-5-yl]-3-Methyl-1-(1-Methylethyl)-
CAS No.:1282516-76-0
Molecular Formula:C15H15BrFN5
Molecular Weight:364.22
Hs Code.:
Mol file:1282516-76-0.mol

Synonyms:1H-1,2,4-Triazole, 5-[2-(4-broMo-2-fluorophenyl)-1H-iMidazol-5-yl]-3-Methyl-1-(1-Methylethyl)-;5-[2-(4-Bromo-2-fluoro-phenyl)-1H-imidazol-4-yl]-1-isopropyl-3-methyl-1H-[1,2,4]triazole

Suppliers and Price of 1H-1,2,4-Triazole, 5-[2-(4-broMo-2-fluorophenyl)-1H-iMidazol-5-yl]-3-Methyl-1-(1-Methylethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
5-(2-(4-Bromo-2-fluorophenyl)-1H-imidazol-5-yl)-1-isopropyl-3-methyl-1H-1,2,4-triazole 95+%
250mg
$ 1800.00

Total 6 raw suppliers

Chemical Property of 1H-1,2,4-Triazole, 5-[2-(4-broMo-2-fluorophenyl)-1H-iMidazol-5-yl]-3-Methyl-1-(1-Methylethyl)-

Chemical Property:

Boiling Point:569.6±60.0 °C(Predicted)
PKA:9.69±0.12(Predicted)
PSA：59.39000
Density:1.57±0.1 g/cm3(Predicted)
LogP:4.12610

Purity/Quality:

97% ^*data from raw suppliers

5-(2-(4-Bromo-2-fluorophenyl)-1H-imidazol-5-yl)-1-isopropyl-3-methyl-1H-1,2,4-triazole 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1H-1,2,4-Triazole, 5-[2-(4-broMo-2-fluorophenyl)-1H-iMidazol-5-yl]-3-Methyl-1-(1-Methylethyl)-

There total 13 articles about 1H-1,2,4-Triazole, 5-[2-(4-broMo-2-fluorophenyl)-1H-iMidazol-5-yl]-3-Methyl-1-(1-Methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1282517-46-7
2-bromo-1-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-ethanone

: 4-bromo-2-fluoro-benzamidine hydrochloride

: 1282516-76-0
5-(2-(4-bromo-2-fluorophenyl)-1H-imidazol-4-yl)-1-isopropyl-3-methyl-1H-1,2,4-triazole

Guidance literature:: With potassium hydrogencarbonate; In tetrahydrofuran; water; for 18h; Reflux;

Reference yield:

: 4-bromo-2-fluorobenzimidamide hydrochloride

: 2-chloro-1-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)ethanone

: 1282516-76-0
5-(2-(4-bromo-2-fluorophenyl)-1H-imidazol-4-yl)-1-isopropyl-3-methyl-1H-1,2,4-triazole

Guidance literature:: 4-bromo-2-fluorobenzimidamide hydrochloride; With potassium hydrogencarbonate; In tetrahydrofuran; water; at 60 ℃;

2-chloro-1-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)ethanone; In tetrahydrofuran; water; at 60 - 65 ℃; for 24h;

Reference yield:

: 3742-63-0
acetic acid isopropylidenehydrazide

: 1282516-76-0
5-(2-(4-bromo-2-fluorophenyl)-1H-imidazol-4-yl)-1-isopropyl-3-methyl-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / platinum(IV) oxide / industrial methylated spirits / 48 h / 20 °C

2.1: trimethoxonium tetrafluoroborate / dichloromethane / 2 h / 20 °C

2.2: 15 h / 20 °C / Reflux

3.1: 1,1-dibromomethane; methyllithium / formaldehyde diethyl acetal / 0.25 h / -78 °C

3.2: -78 - 20 °C

4.1: potassium hydrogencarbonate / water; tetrahydrofuran / 18 h / Reflux

With methyllithium; hydrogen; trimethoxonium tetrafluoroborate; potassium hydrogencarbonate; 1,1-dibromomethane; platinum(IV) oxide; In tetrahydrofuran; industrial methylated spirits; formaldehyde diethyl acetal; dichloromethane; water;