Ethanone, 1-(5-fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-

Base Information

Chemical Name:Ethanone, 1-(5-fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-
CAS No.:1132610-47-9
Molecular Formula:C₁₄H₁₁FN₄O
Molecular Weight:270.266
Hs Code.:2933990090
Mol file:1132610-47-9.mol

Synonyms:Ethanone, 1-(5-fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-;1-(5-Fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-ethanone

Suppliers and Price of Ethanone, 1-(5-fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-([1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YL)-1-(5-FLUORO-6-METHYLPYRIDIN-2-YL)ETHANONE 95.00%
5MG
$ 500.27

Alichem
2-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-1-(5-fluoro-6-methylpyridin-2-yl)ethanone
1g
$ 640.56

Total 6 raw suppliers

Chemical Property of Ethanone, 1-(5-fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-

Chemical Property:

PSA：60.15000
LogP:1.99720
Storage Temp.:2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-([1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YL)-1-(5-FLUORO-6-METHYLPYRIDIN-2-YL)ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(5-fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-

There total 3 articles about Ethanone, 1-(5-fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 614750-81-1
[1,2,4]-triazolo[1,5-a]pyridine-6-carbaldehyde

: 1132610-60-6
diphenyl(5-fluoro-6-methylpyridin-2-yl)(phenylamino)methylphosphonate

: 1132610-47-9
2-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1-(5-fluoro-6-methylpyridin-2-yl)ethanone

Guidance literature:: [1,2,4]-triazolo[1,5-a]pyridine-6-carbaldehyde; diphenyl(5-fluoro-6-methylpyridin-2-yl)(phenylamino)methylphosphonate; With caesium carbonate; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 24h;

With hydrogenchloride; In tetrahydrofuran; isopropyl alcohol; for 1h;
DOI:10.1016/j.bmcl.2015.09.058

Reference yield:

: 3-fluoro-6-iodo-2-methylpyridine

: 1132610-47-9
2-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1-(5-fluoro-6-methylpyridin-2-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride / dichloromethane; tetrahydrofuran / 2 h / -20 °C / Inert atmosphere

1.2: 12 h / -20 - 20 °C / Inert atmosphere

2.1: isopropyl alcohol / 20 °C

3.1: caesium carbonate / tetrahydrofuran; isopropyl alcohol / 24 h / 20 °C

3.2: 1 h

With isopropylmagnesium chloride; caesium carbonate; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2015.09.058

Reference yield:

: 374633-38-2
2-bromo-5-fluoro-6-methyl-2-pyridine

: 1132610-47-9
2-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1-(5-fluoro-6-methylpyridin-2-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 48 h / 90 °C / Sealed tube

2.1: isopropylmagnesium chloride / dichloromethane; tetrahydrofuran / 2 h / -20 °C / Inert atmosphere

2.2: 12 h / -20 - 20 °C / Inert atmosphere

3.1: isopropyl alcohol / 20 °C

4.1: caesium carbonate / tetrahydrofuran; isopropyl alcohol / 24 h / 20 °C

4.2: 1 h

With chloro-trimethyl-silane; isopropylmagnesium chloride; caesium carbonate; sodium iodide; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmcl.2015.09.058