Phosphonic acid, P-[(5-fluoro-6-Methyl-2-pyridinyl)(phenylaMino)Methyl]-, diphenyl ester

Base Information

Chemical Name:Phosphonic acid, P-[(5-fluoro-6-Methyl-2-pyridinyl)(phenylaMino)Methyl]-, diphenyl ester
CAS No.:1132610-60-6
Molecular Formula:C25H22FN2O3P
Molecular Weight:448.433
Hs Code.:
Mol file:1132610-60-6.mol

Synonyms:Phosphonic acid, P-[(5-fluoro-6-Methyl-2-pyridinyl)(phenylaMino)Methyl]-, diphenyl ester

Suppliers and Price of Phosphonic acid, P-[(5-fluoro-6-Methyl-2-pyridinyl)(phenylaMino)Methyl]-, diphenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Diphenyl((5-fluoro-6-methylpyridin-2-yl)(phenylamino)methyl)phosphonate 95+%
1g
$ 947.00

Chemenu
diphenyl((5-fluoro-6-methylpyridin-2-yl)(phenylamino)methyl)phosphonate 95%
1g
$ 893.00

American Custom Chemicals Corporation
DIPHENYL-((5-FLUORO-6-METHYLPYRIDIN-2-YL)(PHENYLAMINO)METHYL)PHOSPHONATE 95.00%
5MG
$ 495.84

Total 2 raw suppliers

Chemical Property of Phosphonic acid, P-[(5-fluoro-6-Methyl-2-pyridinyl)(phenylaMino)Methyl]-, diphenyl ester

Chemical Property:

PSA：70.26000
LogP:7.06390
Storage Temp.:2-8°C

Purity/Quality:: Diphenyl((5-fluoro-6-methylpyridin-2-yl)(phenylamino)methyl)phosphonate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Phosphonic acid, P-[(5-fluoro-6-Methyl-2-pyridinyl)(phenylaMino)Methyl]-, diphenyl ester

There total 3 articles about Phosphonic acid, P-[(5-fluoro-6-Methyl-2-pyridinyl)(phenylaMino)Methyl]-, diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 4712-55-4
diphenyl hydrogen phosphite

: 884495-34-5
5-fluoro-6-methyl-2-pyridinecarboxaldehyde

: 62-53-3
aniline

: 1132610-60-6
diphenyl(5-fluoro-6-methylpyridin-2-yl)(phenylamino)methylphosphonate

Guidance literature:: In isopropyl alcohol; at 20 ℃;
DOI:10.1016/j.bmcl.2015.09.058

Reference yield:

: 3-fluoro-6-iodo-2-methylpyridine

: 1132610-60-6
diphenyl(5-fluoro-6-methylpyridin-2-yl)(phenylamino)methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / dichloromethane; tetrahydrofuran / 2 h / -20 °C / Inert atmosphere

1.2: 12 h / -20 - 20 °C / Inert atmosphere

2.1: isopropyl alcohol / 20 °C

With isopropylmagnesium chloride; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2015.09.058

Reference yield:

: 374633-38-2
2-bromo-5-fluoro-6-methyl-2-pyridine

: 1132610-60-6
diphenyl(5-fluoro-6-methylpyridin-2-yl)(phenylamino)methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 48 h / 90 °C / Sealed tube

2.1: isopropylmagnesium chloride / dichloromethane; tetrahydrofuran / 2 h / -20 °C / Inert atmosphere

2.2: 12 h / -20 - 20 °C / Inert atmosphere

3.1: isopropyl alcohol / 20 °C

With chloro-trimethyl-silane; isopropylmagnesium chloride; sodium iodide; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmcl.2015.09.058