5-Ethoxy-2-pyridinecarboxylic acid

Base Information

• Chemical Name: 5-Ethoxy-2-pyridinecarboxylic acid
• CAS No.: 98353-08-3
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Hs Code.: 2933399090
• Mol file: 98353-08-3.mol

Synonyms:5-Ethoxy-2-pyridinecarboxylic acid

Chemical Property of 5-Ethoxy-2-pyridinecarboxylic acid

Chemical Property:

• Boiling Point: 321.3±22.0 °C(Predicted)
• PKA: 1.08±0.50(Predicted)
• PSA: 59.42000
• Density: 1.231±0.06 g/cm3(Predicted)
• LogP: 1.17850
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

5-Ethoxypicolinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Ethoxy-2-pyridinecarboxylic acid

There total 2 articles about 5-Ethoxy-2-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.3%

methyl 5-ethoxypyridin-2-carboxylate (941306-58-7) → 5-ethoxypicolinic acid (98353-08-3)

Guidance literature:

With methanol; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

methyl 5-hydroxypicolinate (30766-12-2) → 5-ethoxypicolinic acid (98353-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2: lithium hydroxide; methanol / tetrahydrofuran / 3 h / 20 °C

With methanol; potassium carbonate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 82.0%

5-ethoxypicolinic acid (98353-08-3) + 3-chloro-aniline (108-42-9) → N-(3-chlorophenyl)-5-ethoxypicolinamide

Guidance literature:

5-ethoxypicolinic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;

3-chloro-aniline; In N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.1c01264

upstream raw materials:

methyl 5-ethoxypyridin-2-carboxylate

methyl 5-hydroxypicolinate

Downstream raw materials:

C₁₉H₁₉F₃N₄O₃

N-(2-chlorophenyl)-5-ethoxypicolinamide

Refernces