Methyl 5-ethoxypicolinate

Base Information

• Chemical Name: Methyl 5-ethoxypicolinate
• CAS No.: 941306-58-7
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.191
• Mol file: 941306-58-7.mol

Synonyms:

Chemical Property of Methyl 5-ethoxypicolinate

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-ethoxypicolinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 5-ethoxypicolinate

There total 4 articles about Methyl 5-ethoxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 5-hydroxypicolinate (30766-12-2) + ethyl iodide (75-03-6) → methyl 5-ethoxypyridin-2-carboxylate (941306-58-7)

Guidance literature:

With potassium carbonate; In acetone; at 20 - 50 ℃; for 41h;

DOI:10.1021/acs.jmedchem.1c01264

Reference yield:

2-ethoxyprop-2-enal (2648-49-9) → methyl 5-ethoxypyridin-2-carboxylate (941306-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 68.9 percent / potassium carbonate / diethyl ether / 5 h / Heating

2: 56.07 percent / hydroquinone / benzene / 6.6 h / 100 °C

3: 2556.75 h / 8 °C

With potassium carbonate; hydroquinone; In diethyl ether; benzene;

DOI:10.1134/S1070428006100010

Reference yield:

2-ethoxyprop-2-enal dimethylhydrazone (941306-53-2) → methyl 5-ethoxypyridin-2-carboxylate (941306-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 56.07 percent / hydroquinone / benzene / 6.6 h / 100 °C

2: 2556.75 h / 8 °C

With hydroquinone; In benzene;

DOI:10.1134/S1070428006100010

upstream raw materials:

methyl 1-dimethylamino-5-ethoxy-1,2,3,4-tetrahydropyridin-2-carboxylate

2-ethoxyprop-2-enal dimethylhydrazone

2-ethoxyprop-2-enal

methyl 5-hydroxypicolinate

Downstream raw materials:

5-ethoxypicolinic acid