4-Methoxy-β-carboline

Base Information

• Chemical Name: 4-Methoxy-β-carboline
• CAS No.: 56666-88-7
• Molecular Formula: C12H10N2O
• Molecular Weight: 198.224
• Mol file: 56666-88-7.mol

Synonyms:4-Methoxy-9H-pyrido[3,4-b]indole;4-Methoxy-β-carboline

Chemical Property of 4-Methoxy-β-carboline

Chemical Property:

• PSA: 37.91000
• LogP: 2.72470

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-Methoxy-9H-pyrido[3,4-b]indole 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methoxy-β-carboline

There total 17 articles about 4-Methoxy-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(toluene-4-sulfonyl)-1,2,3,9-tetrahydro-β-carbolin-4-one (854545-80-5) + 2,2-dimethoxy-propane (77-76-9) → 4-methoxy-β-carboline (56666-88-7)

Guidance literature:

With boron trifluoride diethyl etherate; In 1,1,2,2-tetrachloroethane; at 120 ℃; for 0.2h;

DOI:10.1016/j.tetlet.2005.03.177

Reference yield: 72.0%

2-formyl-4-oxo-1,2,3,4-tetrahydro-β-carboline (137937-05-4) + 2,2-dimethoxy-propane (77-76-9) → 4-methoxy-β-carboline (56666-88-7)

Guidance literature:

With chloranil; toluene-4-sulfonic acid; In benzene; for 12h; Ambient temperature;

DOI:10.1016/S0040-4020(96)01112-X

Reference yield: 65.0%

9-benzyl-4-methoxy-β-carboline (137937-00-9) → 4-methoxy-β-carboline (56666-88-7)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; -40 deg C, 1 h; r.t., overnight;

DOI:10.1016/0040-4039(95)00126-W

upstream raw materials:

methanol

2-Benzamido-4-oxo-1,2,3,4-tetrahydro β-carboline

2-formyl-4-oxo-1,2,3,4-tetrahydro-β-carboline

2,2-dimethoxy-propane

Downstream raw materials:

4-methoxy-β-carboline-1-carboxylic acid methyl ester