5-ALLYL-2,6-DIMETHYL-4-PYRIMIDINOL

Base Information

• Chemical Name: 5-ALLYL-2,6-DIMETHYL-4-PYRIMIDINOL
• CAS No.: 78304-54-8
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.207
• Hs Code.: 2933599090
• Mol file: 78304-54-8.mol

Synonyms:5-ALLYL-2,6-DIMETHYL-4-PYRIMIDINOL;5-ALLYL-2,6-DIMETHYL-PYRIMIDIN-4-OL

Chemical Property of 5-ALLYL-2,6-DIMETHYL-4-PYRIMIDINOL

Chemical Property:

• Vapor Pressure: 0.0235mmHg at 25°C
• Boiling Point: 249°C at 760 mmHg
• Flash Point: 104.4°C
• PSA: 46.01000
• Density: 1.07g/cm³
• LogP: 1.52750

Purity/Quality:

5-Allyl-2,6-dimethylpyrimidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-ALLYL-2,6-DIMETHYL-4-PYRIMIDINOL

There total 2 articles about 5-ALLYL-2,6-DIMETHYL-4-PYRIMIDINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetamidine hydrochloride (124-42-5) + 2-acetyl-pent-4-enoic acid ethyl ester (610-89-9,84984-48-5) → 5-allyl-2,4-dimethyl-1,6-dihydropyrimidin-6-one (78304-54-8)

Guidance literature:

With NaOEt; In ethanol; water;

Reference yield:

acetamidine (143-37-3) + 2-acetyl-pent-4-enoic acid ethyl ester (610-89-9,84984-48-5) → 5-allyl-2,4-dimethyl-1,6-dihydropyrimidin-6-one (78304-54-8)

Guidance literature:

With ethanol;

Reference yield:

2,4-dimethyl-5-allyl-6-hydroxypyrimidine (78304-54-8) → 2,4-dimethyl-5,6-dihydro-6-bromomethylthieno<2,3-d>pyrimidine (81401-31-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / phosphorus oxychloride, dimethylaniline / 4 h / Heating

2: 97.4 percent / acetone / 3 h / Heating

4: 60.2 percent / bromine / ethanol / 4 h / Heating

With bromine; 2,3-Dimethylaniline; trichlorophosphate; In ethanol; acetone;

DOI:10.1007/BF00513299

upstream raw materials:

acetamidine

2-acetyl-pent-4-enoic acid ethyl ester

acetamidine hydrochloride

Downstream raw materials:

2,4-dimethyl-5,6-dihydro-6-bromomethylthieno<2,3-d>pyrimidine

Refernces

• 1、 -. "Substituted aminopyrimidines as antihypertensives". . . Retrieved 2008/06/13.