2-Methyl-3-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 2-Methyl-3-(trifluoromethyl)pyridine
• CAS No.: 106877-18-3
• Molecular Formula: C₇H₆F₃N
• Molecular Weight: 161.127
• Hs Code.: 2933399990
• Mol file: 106877-18-3.mol

Synonyms:2-Methyl-3-(trifluoromethyl)pyridine

Chemical Property of 2-Methyl-3-(trifluoromethyl)pyridine

Chemical Property:

• PSA: 12.89000
• LogP: 2.40880
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Methyl-3-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-3-(trifluoromethyl)pyridine

There total 3 articles about 2-Methyl-3-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

→ 2-methyl-3-(trifluoromethyl)pyridine (106877-18-3)

Guidance literature:

Reference yield: 1.0%

α-picoline (109-06-8) + Bromotrifluoromethane (75-63-8) → 2-methyl-6-(trifluoromethyl)pyridine (1620-72-0) + 2-Methyl-5-(trifluoromethyl)pyridine (31181-54-1) + 2-methyl-4-(trifluoromethyl)pyridine (106877-17-2) + 2-methyl-3-(trifluoromethyl)pyridine (106877-18-3)

Guidance literature:

With sodium metabisulfite; sulfur dioxide; zinc; In N,N-dimethyl-formamide; at 65 ℃; for 3h; under 5250.4 - 6000.5 Torr;

Reference yield:

trifluoromethylcopper(I) (77152-08-0) + 3-bromo-2-picoline (38749-79-0) → 2-methyl-3-(trifluoromethyl)pyridine (106877-18-3)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In N,N-dimethyl-formamide; at 23 - 60 ℃; for 15h; Glovebox; Sealed tube;

DOI:10.1021/jo401423h

upstream raw materials:

α-picoline

Bromotrifluoromethane

trifluoromethylcopper(I)

3-bromo-2-picoline

Refernces

• 1、 Tordeux, Marc,Langlois, Bernard,Wakselman, Claude. "Reactions of Trifluoromethyl Bromide and Related Halides: Part 10. Perfluoroalkylation of Aromatic Compounds induced by Sulphur Dioxide Radical Anion Precursors". . p. 2293 - 2299. Retrieved 2007/10/02.